Department of Chemistry and Institute of Chemical Biology & Drug Discovery, Stony Brook University, Stony Brook, NY 11794-3400, USA.
Int J Mol Sci. 2013 Aug 8;14(8):16473-84. doi: 10.3390/ijms140816473.
Cell signaling plays an important role in the survival of bacterial colonies. They use small molecules to coordinate gene expression in a cell density dependent manner. This process, known as quorum sensing, helps bacteria regulate diverse functions such as bioluminescence, biofilm formation and virulence. In Vibrio harveyi, a bioluminescent marine bacterium, four parallel quorum-sensing systems have been identified to regulate light production. We have previously reported that nitric oxide (NO), through the H-NOX/HqsK quorum sensing pathway contributes to light production in V. harveyi through the LuxU/LuxO/LuxR quorum sensing pathway. In this study, we show that nitric oxide (NO) also regulates flagellar production and enhances biofilm formation. Our data suggest that V. harveyi is capable of switching between lifestyles to be able to adapt to changes in the environment.
细胞信号转导在细菌菌落的存活中起着重要作用。它们使用小分子以依赖于细胞密度的方式协调基因表达。这个过程被称为群体感应，有助于细菌调节多种功能，如生物发光、生物膜形成和毒力。在发光海洋细菌 Harveyi 弧菌中，已经确定了四个平行的群体感应系统来调节光的产生。我们之前曾报道过，一氧化氮 (NO) 通过 H-NOX/HqsK 群体感应途径，通过 LuxU/LuxO/LuxR 群体感应途径促进 Harveyi 弧菌的发光。在这项研究中，我们表明一氧化氮 (NO) 还调节鞭毛产生并增强生物膜形成。我们的数据表明，Harveyi 弧菌能够在生活方式之间切换，以适应环境变化。
