Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Int J Mol Sci. 2013 Aug 20;14(8):17157-67. doi: 10.3390/ijms140817157.
Brain metastases are a much-feared complication of cancer. The development of brain metastases requires a malignant cell to acquire characteristics that facilitate dissemination away from the primary site, entrance into the nervous system, and establishment in the brain. This review summarizes recent work focused on the molecular derangements leading to brain metastases and outlines areas in need of greater understanding.
脑转移是癌症患者非常担心的并发症。脑转移的发展需要恶性细胞获得促进其从原发部位扩散、进入神经系统并在大脑中建立的特征。这篇综述总结了最近关于导致脑转移的分子失调的研究工作，并概述了需要进一步了解的领域。
