衰老过程中的下丘脑炎症与促性腺激素释放激素 - Suppr

Hypothalamic inflammation and GnRH in aging development.

作者信息

Tang Yizhe, Cai Dongsheng

机构信息

Department of Molecular Pharmacology, Diabetes Research and Training Center, and Institute of Aging; Albert Einstein College of Medicine; Bronx, NY USA.

出版信息

Cell Cycle. 2013 Sep 1;12(17):2711-2. doi: 10.4161/cc.26054. Epub 2013 Aug 19.

DOI:10.4161/cc.26054

PMID:23966154

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3899179/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0402/3899179/e17c07a5e293/cc-12-2711-g1.jpg

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Hypothalamic inflammation and GnRH in aging development.衰老过程中的下丘脑炎症与促性腺激素释放激素

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The hallmarks of aging.衰老的特征。

Cell. 2013 Jun 6;153(6):1194-217. doi: 10.1016/j.cell.2013.05.039.

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH.下丘脑对系统衰老的编程作用涉及 IKK-β、NF-κB 和 GnRH。

Nature. 2013 May 9;497(7448):211-6. doi: 10.1038/nature12143. Epub 2013 May 1.

IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes.IKKβ/NF-κB 破坏成年下丘脑神经干细胞，介导饮食肥胖和前驱糖尿病的神经退行性机制。

Nat Cell Biol. 2012 Oct;14(10):999-1012. doi: 10.1038/ncb2562. Epub 2012 Sep 2.

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