Academic Department of Child Health, University Hospital of North Staffordshire, Stoke-on-Trent, United Kingdom.
J Clin Microbiol. 2013 Nov;51(11):3849-51. doi: 10.1128/JCM.02157-13. Epub 2013 Aug 21.
Biofilm cultures of Burkholderia cepacia complex (BCC) infection have been found to generate the nonvolatile cyanide ion. We investigated if gaseous hydrogen cyanide (HCN) was a marker of BCC infection. Selected ion flow tube mass spectrometry analysis showed HCN was not elevated in the headspace of planktonic or biofilm cultures or in the exhaled breath of adult cystic fibrosis patients with chronic BCC infection. HCN is therefore not an in vitro or in vivo marker of BCC.
生物膜培养的洋葱伯克霍尔德菌复合群（BCC）感染已被发现会产生非挥发性氰化物离子。我们研究了气态氢氰酸（HCN）是否是 BCC 感染的标志物。选择离子流管质谱分析显示，浮游或生物膜培养物的顶空或慢性 BCC 感染的成年囊性纤维化患者的呼气中 HCN 并未升高。因此，HCN 不是 BCC 的体外或体内标志物。
