International Lyme and Associated Diseases Society Bethesda, MD, USA.
Front Cell Infect Microbiol. 2013 Aug 14;3:40. doi: 10.3389/fcimb.2013.00040. eCollection 2013.
Lyme disease is the most common tickborne illness in the world today. A recent study describes for the first time an enzyme produced by the spirochetal agent of Lyme disease, Borrelia burgdorferi, that cleaves aggrecan, a proteoglycan found in joints and connective tissue. Discovery of the spirochetal aggrecanase raises many questions about the pathogenesis of Lyme arthritis and lends support to the concept of persistent B. burgdorferi infection in patients with chronic Lyme disease symptoms.
莱姆病是当今世界最常见的蜱传疾病。最近的一项研究首次描述了莱姆病螺旋体病原体伯氏疏螺旋体产生的一种酶，这种酶能裂解关节和结缔组织中存在的蛋白聚糖聚集蛋白。螺旋体聚集蛋白水解酶的发现提出了许多关于莱姆关节炎发病机制的问题，并为慢性莱姆病症状患者存在持续性伯氏疏螺旋体感染的概念提供了支持。
