Gadalov V P, Salo M, Mansikka M, Pellineĭmi T T, Kuz'mina E G, Liasko L I
Anesteziol Reanimatol. 1990 May-Jun(3):26-30.
The effect of short-acting barbiturates on the number of theophylline-resistant and theophylline-sensitive T-lymphocytes in donors and patients with lung cancer on the function of spontaneous and induced donor regulators as well as the concentration of cyclic nucleotides and T-lymphocytes in donors has been studied in vitro. The effect of general anesthesia with barbiturates on the number of lymphocyte populations and subpopulations in the peripheral blood of somatically healthy patients with minimum surgical trauma has also been assessed. These studies as well as previous investigations serve the basis for elucidating the impact of general anesthesia with barbiturates on the immunity. It is recommended to identify the nature of immunodepression in patients with preoperative immune deficiencies.
已在体外研究了短效巴比妥类药物对肺癌供体和患者中对茶碱耐药和对茶碱敏感的T淋巴细胞数量、对供体自发和诱导调节因子功能以及供体中环核苷酸和T淋巴细胞浓度的影响。还评估了巴比妥类药物全身麻醉对手术创伤最小的躯体健康患者外周血中淋巴细胞群体和亚群数量的影响。这些研究以及先前的调查为阐明巴比妥类药物全身麻醉对免疫的影响奠定了基础。建议确定术前存在免疫缺陷患者免疫抑制的性质。
