Biological Sciences Institute - University of Brasília - Asa Norte, Brasília - Distrito Federal - Brazil. CEP 70910-900.
Curr Protein Pept Sci. 2013 Nov;14(7):588-94. doi: 10.2174/1389203711209070632.
Biotechnology and nanotechnology are fields of science that can be applied together to solve a variety of biological issues. In the case of human health, biotechnology attempts to improve advances on the therapy against several diseases. Therapeutic peptides and proteins are promissory molecules for developing new medicines. Gene transfection and RNA interference have been considered important approaches for modern therapy to treat cancer and viral infections. However, because of their instability, these molecules alone cannot be used for in vivo application, since they are easily degraded or presenting a poor efficiency. Nanotechnology can contribute by the development of nanostructured delivery systems to increase the stability and potency of these molecules. Studies involving polymeric and magnetic nanoparticles, dendrimers, and carbon nanotubes have demonstrated a possibility to use these systems as vectors instead of the conventional viral ones, which present adverse effects, such as recombination and immunogenicity. This review presents some possibilities and strategies to efficiently delivery peptides, proteins, gene and RNA interference using nanotechnology approach.
生物技术和纳米技术是可以结合应用于解决各种生物学问题的科学领域。在人类健康方面，生物技术试图改进对多种疾病的治疗方法。治疗性肽和蛋白质是开发新药的有前途的分子。基因转染和 RNA 干扰已被认为是现代癌症和病毒感染治疗的重要方法。然而，由于它们的不稳定性，这些分子本身不能用于体内应用，因为它们很容易被降解或效率低下。纳米技术可以通过开发纳米结构的递药系统来增加这些分子的稳定性和效力。涉及聚合物和磁性纳米粒子、树枝状大分子和碳纳米管的研究表明，这些系统有可能作为载体替代传统的病毒载体，后者存在重组和免疫原性等不良影响。本文综述了利用纳米技术有效递送肽、蛋白质、基因和 RNA 干扰的一些可能性和策略。
