Movement Disorders Program, Department of Neurology, Georgia Regents University, 1429 Harper Street, HF-1154, Augusta, GA 30912, USA.
Parkinsonism Relat Disord. 2013 Nov;19(11):1039-42. doi: 10.1016/j.parkreldis.2013.07.014. Epub 2013 Aug 20.
Parkinson's disease (PD) impairs both activities of daily living (ADLs) and motor function and has adverse effects on mood in many patients. While dopaminergic medications are quite helpful for motor and ADLs impairments in PD, complementary therapies are also important in helping patients achieve maximum benefits and quality of life. We hypothesized that the Nintendo Wii (Wii) is a useful tool in improving motor and non-motor aspects in patients with PD, given its ability to drive functional movements and interactive nature. We enrolled twenty subjects with early to mid-stage PD in an open-label within-subjects study design where each subject was evaluated at baseline and then re-evaluated after playing the Wii three times per week for four weeks. Subjects were then re-evaluated one month later after not playing the Wii for a month to see if effects carried over. Subjects demonstrated significant improvements in the primary outcome measure (Nottingham Extended Activities of Daily Living Test (NEADL)), quality of life (PDQ-39) and motor function (UPDRS), and a trend toward improved mood (HAM-D) after four weeks of Wii therapy. Follow-up assessments one month later showed continued improvement for quality of life and UPDRS scores. The results demonstrate that Wii therapy provides short-term motor, non-motor, and quality of life benefits in PD. Further studies are needed to determine if there are long-term benefits of Wii therapy in PD.
帕金森病（PD）会损害患者的日常生活活动（ADL）和运动功能，并对其情绪产生负面影响。虽然多巴胺能药物对 PD 患者的运动和 ADL 障碍非常有帮助，但补充疗法对于帮助患者获得最大益处和生活质量也很重要。鉴于其驱动功能性运动和互动的能力，我们假设任天堂 Wii（Wii）是改善 PD 患者运动和非运动方面的有用工具。我们招募了二十名处于早期至中期 PD 的受试者，进行了一项开放标签的自身对照研究设计，每位受试者在基线时进行评估，然后在每周玩三次 Wii 四周后进行重新评估。一个月后，受试者不再玩 Wii 一个月后进行再次评估，以观察效果是否持续。经过四周的 Wii 治疗后，受试者在主要观察指标（诺丁汉扩展日常生活活动测试（NEADL））、生活质量（PDQ-39）和运动功能（UPDRS）方面均有显著改善，情绪（HAM-D）也有改善趋势。一个月后的随访评估显示，生活质量和 UPDRS 评分持续改善。研究结果表明，Wii 疗法可在 PD 患者中提供短期的运动、非运动和生活质量获益。需要进一步的研究来确定 Wii 疗法在 PD 中的长期获益。
