Song Xue-qin, Chen Xu-mei, Zhang Wei, Li Xue, Hei Gang-rui, Li You-hui, Hao Yi-hui, Lü Lu-xian
Department of Psychiatry, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China. Email:
Department of Psychiatry, Second Affiliated Hospital, Xinxiang Medical University, Xinxiang 453002, China. Email:
Zhonghua Yi Xue Za Zhi. 2013 Nov 5;93(41):3256-60.
To explore the levels of adiponectin (APN), interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in first episode drug naїve schizophrenics and further examine the role of adipocytokines in schizophrenia.
Ninety-six normal weight schizophrenics and 22 overweight/obese ones from First Affiliated Hospital, Zhengzhou University and 60 healthy controls were enrolled. Serum levels of IL-1β, IL-6, TNF-α and APN were measured with enzyme linked immunosorbent assay (ELISA).
Serum levels of IL-1β, IL-6 and TNF-α in normal weight schizophrenics (54 ± 13, 34 ± 12, 48 ± 18) pg/ml and overweight/obese schizophrenics (71 ± 21, 40 ± 12, 53 ± 18) pg/ml were significantly higher than those in the controls (23 ± 16, 16 ± 7, 32 ± 15) pg/ml (P < 0.05). Serum levels of IL-1β and IL-6 in overweight/obese schizophrenics were significantly higher than those in normal weight schizophrenics (P < 0.05). Serum level of adiponectin in normal weight schizophrenics was significantly higher than that in control group [(12 ± 4) vs (9 ± 4) pg/ml, P < 0.05].
The serum levels of APN, IL-1β, IL-6 and TNF-α increase in first episode drug naїve schizophrenics. It suggests that an inflammatory response mediated by adipocytokines. APN may play a pro-inflammatory role in schizophrenia.
探讨首发未用药精神分裂症患者脂联素（APN）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）的水平，并进一步研究脂肪细胞因子在精神分裂症中的作用。
纳入郑州大学第一附属医院96例体重正常的精神分裂症患者、22例超重/肥胖的精神分裂症患者以及60例健康对照者。采用酶联免疫吸附测定（ELISA）法检测血清中IL-1β、IL-6、TNF-α和APN的水平。
体重正常的精神分裂症患者（54±13、34±12、48±18）pg/ml和超重/肥胖的精神分裂症患者（71±21、40±12、53±18）pg/ml血清中IL-1β、IL-6和TNF-α水平显著高于对照组（23±16、16±7、32±15）pg/ml（P<0.05）。超重/肥胖的精神分裂症患者血清中IL-1β和IL-6水平显著高于体重正常的精神分裂症患者（P<0.05）。体重正常的精神分裂症患者血清脂联素水平显著高于对照组[（12±4）对（9±4）pg/ml，P<0.05]。
首发未用药精神分裂症患者血清中APN、IL-1β、IL-6和TNF-α水平升高。这表明存在由脂肪细胞因子介导的炎症反应。APN可能在精神分裂症中发挥促炎作用。
