Department of Biology, Boston University, 5 Cummington Mall, Boston, MA, USA.
Trends Cell Biol. 2013 Nov;23(11):567-74. doi: 10.1016/j.tcb.2013.07.005. Epub 2013 Aug 19.
Multiple types of cell death exist including necrosis, apoptosis, and autophagic cell death. The Drosophila ovary provides a valuable model to study the diversity of cell death modalities, and we review recent progress to elucidate these pathways. At least five distinct types of cell death occur in the ovary, and we focus on two that have been studied extensively. Cell death of mid-stage egg chambers occurs through a novel caspase-dependent pathway that involves autophagy and triggers phagocytosis by surrounding somatic epithelial cells. For every egg, 15 germline nurse cells undergo developmental programmed cell death, which occurs independently of most known cell death genes. These forms of cell death are strikingly similar to cell death observed in the germlines of other organisms.
存在多种类型的细胞死亡，包括坏死、凋亡和自噬性细胞死亡。果蝇卵巢为研究细胞死亡方式的多样性提供了一个有价值的模型，我们综述了阐明这些途径的最新进展。在卵巢中至少存在五种不同类型的细胞死亡，我们重点关注两种已被广泛研究的细胞死亡方式。中期卵室的细胞死亡通过一种新的半胱氨酸蛋白酶依赖性途径发生，该途径涉及自噬并触发周围体腔上皮细胞的吞噬作用。对于每个卵子，15 个生殖细胞滋养细胞经历发育程序性细胞死亡，其独立于大多数已知的细胞死亡基因发生。这些形式的细胞死亡与在其他生物体生殖系中观察到的细胞死亡非常相似。
