凋亡之神坛：细胞死亡形式缘何如此多样？
The pantheon of the fallen: why are there so many forms of cell death?
机构信息
Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
出版信息
Trends Cell Biol. 2012 Nov;22(11):555-6. doi: 10.1016/j.tcb.2012.08.008. Epub 2012 Sep 17.
Abstract
Cells die by various mechanisms, only some of which have been elucidated in detail. Numerous 'active' forms of cell death exist in which the cell participates in its own death, including apoptosis, programmed necrosis, mitotic catastrophe, and the recently described ferroptosis. Here, we attempt to explain why there are so many different forms of cell death, and propose a distinction between active death that constitutes 'suicide' versus 'sabotage'.
摘要
细胞通过各种机制死亡，其中只有一些机制已被详细阐明。大量“主动”的细胞死亡形式存在，细胞参与自身的死亡，包括细胞凋亡、程序性坏死、有丝分裂灾难，以及最近描述的铁死亡。在这里，我们试图解释为什么会有如此多不同形式的细胞死亡，并提出主动死亡是“自杀”还是“破坏”之间的区别。
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