Institute of Forensic Medicine/Rechtsmedizin, Rostock University Medical Center, St.-Georg-Strasse 108, 18055 Rostock, Germany.
Cardiovasc Pathol. 2014 Jan-Feb;23(1):12-6. doi: 10.1016/j.carpath.2013.07.001. Epub 2013 Aug 19.
Since 1967, numerous case reports have described fibromuscular alterations of the sinus node artery and/or the atrioventricular node artery as a potential cause of death. However, the prevalence of these changes in a healthy population has only rarely been investigated systematically.
The arteries of the cardiac conduction system were studied systematically, by means of routine histology, in 100 cases of victims aged 0 to 40 years with a nonnatural cause of death.
Microscopic alterations were seen in the walls of sinus node arteries in 52 out of 100 cases, in the walls of atrioventricular node arteries in 63/100 cases, and in the walls of small vessels in 60/100 cases.
The results demonstrate that microscopically detectable findings of the cardiac conduction system arteries similar to fibromuscular dysplasia do not indicate a defined disease and should not be considered as a cause of death when there are no macroscopic findings in the coronary arteries.
自 1967 年以来，已有大量病例报告描述了窦房结动脉和/或房室结动脉的纤维肌性改变，认为这是潜在的致死原因。然而，这些变化在健康人群中的发生率很少被系统地调查过。
通过常规组织学方法，对 100 例 0 至 40 岁非自然死亡的受害者的心脏传导系统动脉进行了系统研究。
在 100 例中，52 例窦房结动脉壁、63 例房室结动脉壁和 60 例小血管壁出现了显微镜下的改变。
这些结果表明，类似于纤维肌性发育不良的心脏传导系统动脉的显微镜下可检测到的发现并不表明存在特定的疾病，并且在冠状动脉没有明显发现时，不应将其视为死亡原因。
