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房室结囊性肿瘤及累及冠状动脉分支的纤维肌发育异常所致猝死

Sudden Death Due to Cystic Tumor of the Atrioventricular Node and Fibromuscular Dysplasia Involving Branches of the Coronary Arteries.

作者信息

Farkašová Iannaccone Silvia, Farkaš Daniel, Ginelliová Alžbeta, Švajdler Marián, Laco Ján, Šteiner Ivo, Fröhlichová Lucia

机构信息

From the *Department of Forensic Medicine, Faculty of Medicine, Pavol Jozef Šafárik University; †Medico-Legal and Pathological-Anatomical Department, Health Care Surveillance Authority, Košice, Slovak Republic; ‡Šikl's Department of Pathology, Medical Faculty Hospital, Charles University, Pilsen; §The Fingerland Department of Pathology, Faculty of Medicine and Faculty Hospital, Charles University, Hradec Králové, Czech Republic; and ‖Department of Pathology, Louis Pasteur University Hospital, Košice, Slovak Republic.

出版信息

Am J Forensic Med Pathol. 2018 Mar;39(1):46-49. doi: 10.1097/PAF.0000000000000356.

DOI:10.1097/PAF.0000000000000356
PMID:29095703
Abstract

In this paper, we report the autopsy findings of a 42-year-old White male who was found deceased at his home by his brother in the early morning hours with a history of excessive alcohol consumption 1 day before his death. A medical record review revealed chronic alcohol use with alcohol dependence syndrome, hypertension, and cardiac arrhythmias by electrocardiogram 2 years prior. External examination revealed only a single bruise on the forehead. Internal examination revealed changes associated with chronic alcohol abuse and mild atherosclerosis. The lack of a cause of death at autopsy resulted in a dissection of the cardiac conduction system and the detection of a small cystic lesion at the atrioventricular node region. Microscopic examination revealed a cystic tumor of the atrioventricular node and fibromuscular dysplasia of the coronary artery branches near the sinoatrial and atrioventricular nodes. Based on the case history and autopsy findings, death was attributed to a fatal cardiac arrhythmia due to cystic tumor of the atrioventricular node with fibromuscular dysplasia of the coronary artery branches near the sinoatrial and atrioventricular nodes a possible contributing factor.

摘要

在本文中,我们报告了一名42岁白人男性的尸检结果。该男子于清晨被其兄弟发现死于家中,死前1天有过量饮酒史。病历回顾显示,他有慢性酒精使用伴酒精依赖综合征、高血压,且两年前心电图检查显示有心律失常。外部检查仅发现前额有一处瘀伤。内部检查发现了与慢性酒精滥用和轻度动脉粥样硬化相关的变化。尸检时未发现死因,因此对心脏传导系统进行了解剖,并在房室结区域发现了一个小的囊性病变。显微镜检查显示为房室结囊性肿瘤,以及窦房结和房室结附近冠状动脉分支的纤维肌发育异常。根据病史和尸检结果,死亡归因于致命性心律失常,其原因是房室结囊性肿瘤,而窦房结和房室结附近冠状动脉分支的纤维肌发育异常可能是一个促成因素。

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