Brain Imaging Research Center, Psychiatric Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Psychiatry Res. 2013 Dec 30;214(3):238-46. doi: 10.1016/j.pscychresns.2013.06.003. Epub 2013 Aug 19.
Assaultive violence exposure during childhood is a significant risk factor for posttraumatic stress disorder (PTSD). The purpose of the present study was to characterize the relationships of assault and PTSD severity with the organization of large-scale networks identified during emotion processing. Adolescent girls aged 12-16 with (N=15) and without (N=15) histories of assault underwent functional magnetic resonance imaging (fMRI) while engaged in a task that presented images of fearful or neutral facial expressions. Independent component analysis (ICA) identified a frontocingulate network, a frontoparietal network, and a default mode network. Assault exposure was associated with significantly greater activation of the frontocingulate network for fear versus neutral faces. Within the frontocingulate network, Posttraumatic stress disorder (PTSD) severity was associated with weakened functional connectivity between the left amygdala and the perigenual anterior cingulate. Within the frontoparietal network, assaulted girls demonstrated weakened connectivity of the premotor cortex with the right middle frontal gyrus. Within the default mode network, assault exposure and PTSD severity were associated with strengthening functional connectivity of the parahippocampus with the medial and lateral prefrontal cortex, respectively. Individual differences in functional connections within the frontocingulate network and frontoparietal network among the assaulted group were strongly associated with caregiver-rated family disengagement. These results demonstrate associations between assault and PTSD symptoms with the functional organization of large-scale frontoparietal, frontocingulate, and default mode networks during emotion processing. The relationship with caregiver-rated family disengagement suggests the impact of family support on the neural processing correlates of assault and PTSD symptoms.
童年期遭受攻击暴力是创伤后应激障碍（PTSD）的一个重要风险因素。本研究的目的是描述攻击和 PTSD 严重程度与情绪处理过程中确定的大规模网络组织之间的关系。12-16 岁有（N=15）和无（N=15）攻击史的少女接受了功能磁共振成像（fMRI）检查，同时进行了呈现恐惧或中性面部表情的任务。独立成分分析（ICA）确定了额顶网络、额顶网络和默认模式网络。与中性面孔相比，攻击暴露与额顶网络对恐惧的激活显著增加有关。在额顶网络中，PTSD 严重程度与左杏仁核和扣带回前回之间的功能连接减弱有关。在额顶网络中，被攻击的女孩表现出运动前皮质与右侧额中回之间的连接减弱。在默认模式网络中，攻击暴露和 PTSD 严重程度分别与海马体与内侧和外侧前额叶皮层之间的功能连接增强有关。被攻击组中额顶网络和额顶网络内的功能连接个体差异与照顾者评定的家庭脱节强烈相关。这些结果表明，攻击和 PTSD 症状与情绪处理过程中的额顶、额顶和默认模式网络的功能组织之间存在关联。与照顾者评定的家庭脱节的关系表明了家庭支持对攻击和 PTSD 症状的神经处理相关性的影响。
