Varshavskiĭ V A, Panasiuk N N, Antonov M V, Fal'kovskaia O G
Arkh Patol. 1990;52(5):32-6.
Three variants of psoriatic nephropathy are distinguished on the basis of light microscopical and immunohistochemical study of 23 cases/20 kidney biopsies and 3 autopsy cases/: glomerulonephritis, amyloidosis and minimal kidney alterations. Chronic glomerulonephritis is mainly of a mesangioproliferative type with fixation of IgA and C3 on the mesangium and basal membranes of glomerular capillaries. Psoriatic amyloidosis has morphologically, all the features of acquired amyloidosis/AA-amyloidosis/. Thus psoriatic nephropathy is a reflection of a disturbed homeostasis.
基于对23例(20例肾活检和3例尸检病例)进行的光学显微镜和免疫组织化学研究,鉴别出银屑病肾病的三种变体:肾小球肾炎、淀粉样变性和轻微肾脏改变。慢性肾小球肾炎主要为系膜增生性类型,IgA和C3固定于肾小球系膜和肾小球毛细血管基底膜。银屑病淀粉样变性在形态学上具有获得性淀粉样变性(AA型淀粉样变性)的所有特征。因此,银屑病肾病是内环境稳态紊乱的一种表现。