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多贝斯滴眼液改善干眼疾病的症状和体征。

Improvement in the signs and symptoms of dry eye disease with dobesilate eye drops.

机构信息

Facultad de Medicina, Universidad Alfonso X, Madrid, Spain ; Departamento de Oftalmología, Hospital de Día Pío XII, Madrid, Spain.

Departamento de Oftalmología, Hospital de Día Pío XII, Madrid, Spain.

出版信息

Mil Med Res. 2015 Dec 21;2:35. doi: 10.1186/s40779-015-0068-8. eCollection 2015.

DOI:10.1186/s40779-015-0068-8
PMID:26697189
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4687099/
Abstract

BACKGROUND

Dry eye is a multifactor disease of the tear film and ocular surface that substantially affects quality of life.

CASE PRESENTATION

Dobesilate administered as eye drops was well tolerated and effective in treating both the objective signs and subjective symptoms of dry eye disease in this 2-week study.

CONCLUSION

To the best of our knowledge, this is the first clinical report of using dobesilate in eye drops. Dobesilate may provide a novel approach to treating drying diseases of the eye.

摘要

背景

干眼症是一种多因素的泪膜和眼表疾病，严重影响生活质量。

病例介绍

在这项为期 2 周的研究中，滴用羟苯磺酸钙耐受性良好，且对干眼症的客观体征和主观症状均有效。

结论

据我们所知，这是首次报道羟苯磺酸钙滴眼剂的临床应用。羟苯磺酸钙可能为治疗眼干燥症提供一种新方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9709/4687099/87a8bd61f395/40779_2015_68_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9709/4687099/ac58852cea3e/40779_2015_68_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9709/4687099/c98abef20a1d/40779_2015_68_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9709/4687099/87a8bd61f395/40779_2015_68_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9709/4687099/ac58852cea3e/40779_2015_68_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9709/4687099/c98abef20a1d/40779_2015_68_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9709/4687099/87a8bd61f395/40779_2015_68_Fig3_HTML.jpg

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本文引用的文献

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Upregulation of NLRP3 Inflammasome in the Tears and Ocular Surface of Dry Eye Patients.干眼患者泪液和眼表中NLRP3炎性小体的上调
PLoS One. 2015 May 11;10(5):e0126277. doi: 10.1371/journal.pone.0126277. eCollection 2015.
2
Diacetyloxyl derivatization of the fibroblast growth factor inhibitor dobesilate enhances its anti-inflammatory, anti-angiogenic and anti-tumoral activities.成纤维细胞生长因子抑制剂羟苯磺酸的二乙酰氧基衍生化增强了其抗炎、抗血管生成和抗肿瘤活性。
J Transl Med. 2015 Feb 1;13:48. doi: 10.1186/s12967-015-0413-4.
3
The core mechanism of dry eye disease is inflammation.
一项使用泪液蕨样变试验对正常男性受试者非刺激泪液和刺激泪液质量的比较研究。
Clin Optom (Auckl). 2019 Jul 3;11:65-71. doi: 10.2147/OPTO.S214597. eCollection 2019.
干眼症的核心机制是炎症。
Eye Contact Lens. 2014 Jul;40(4):248-56. doi: 10.1097/ICL.0000000000000042.
4
Dry eye: an inflammatory ocular disease.干眼症：一种炎症性眼病。
J Ophthalmic Vis Res. 2014 Apr;9(2):240-50.
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Topical treatment of contact dermatitis by pine processionary caterpillar.松毒蛾对接触性皮炎的局部治疗
BMJ Case Rep. 2011 Aug 11;2011:bcr0620114351. doi: 10.1136/bcr.06.2011.4351.
6
Long-term effectiveness of dobesilate in the treatment of papulopustular rosacea.羟苯磺酸钙治疗丘疹脓疱型玫瑰痤疮的长期疗效
BMJ Case Rep. 2011 Oct 16;2011:bcr0820114579. doi: 10.1136/bcr.08.2011.4579.
7
b-FGF induces corneal blood and lymphatic vessel growth in a spatially distinct pattern.b-FGF 以空间上独特的模式诱导角膜血管和淋巴管生长。
Cornea. 2012 Jul;31(7):804-9. doi: 10.1097/ICO.0b013e31823f8b5a.
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Dry eye disease: an immune-mediated ocular surface disorder.干眼症：一种免疫介导的眼表疾病。
Arch Ophthalmol. 2012 Jan;130(1):90-100. doi: 10.1001/archophthalmol.2011.364.
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