Ningbo Medical Center, Lihuili Hospital, Ningbo University, Ningbo, Zhejiang 315041, P.R. China.
Mol Med Rep. 2013 Oct;8(4):1175-82. doi: 10.3892/mmr.2013.1642. Epub 2013 Aug 16.
Previous studies have shown that apolipoprotein A5 (APOA5) gene variants are genetic determinants of the concentration of triglycerides, which are a known risk factor for coronary heart disease (CHD). Using the standardized coronary angiography method, 290 CHD patients and 198 non‑CHD controls were recruited from Ningbo Lihuili Hospital. In addition, 331 unrelated healthy volunteers were recruited as healthy controls from Ningbo Ximen Community residents. Three variants of the APOA5 gene, S19W, ‑1131T>C and 553G>T, were analyzed for their association with CHD. Under a dominant inheritance model, ‑1131CT>C was shown to be a CHD risk factor (P=0.030; OR, 1.422; 95% CI, 1.036‑1.952). The single nucleotide polymorphism, 553G>T, was found to correlate with the severity of CHD in males (P=0.032). Meta‑analysis showed that ‑1131T>C was significantly associated with CHD (P<0.0001). By contrast, negative correlations with CHD were observed for S19W and 553G>T. In the present case‑control study, APOA5 gene variants were not found to correlate with the risk of CHD in the populations studied; however, ‑1131CT>C was shown to be a CHD risk factor under a dominant inheritance model. Meta‑analysis showed a significant contribution of ‑1131T>C to the risk of CHD, implying an ethnic difference in APOA5 gene variants.
先前的研究表明载脂蛋白 A5（APOA5）基因变异是甘油三酯浓度的遗传决定因素，甘油三酯是冠心病（CHD）的已知风险因素。采用标准化的冠状动脉造影方法，从宁波李惠利医院招募了 290 名 CHD 患者和 198 名非 CHD 对照者。此外，从宁波西门社区居民中招募了 331 名无关的健康志愿者作为健康对照者。分析了 APOA5 基因的三个变体，S19W、-1131T>C 和 553G>T，以研究它们与 CHD 的关联。在显性遗传模型下，-1131CT>C 被证明是 CHD 的危险因素（P=0.030；OR，1.422；95%CI，1.036-1.952）。单核苷酸多态性 553G>T 与男性 CHD 的严重程度相关（P=0.032）。荟萃分析表明，-1131T>C 与 CHD 显著相关（P<0.0001）。相比之下，S19W 和 553G>T 与 CHD 呈负相关。在本病例对照研究中，未发现 APOA5 基因变异与研究人群的 CHD 风险相关；然而，在显性遗传模型下，-1131CT>C 被证明是 CHD 的危险因素。荟萃分析表明，-1131T>C 对 CHD 的风险有显著贡献，这表明 APOA5 基因变异存在种族差异。
