Department of Neurology, Faculty of Medicine, Safarik University and L. Pasteur University Hospital, Kosice, Slovak Republic.
J Geriatr Psychiatry Neurol. 2013 Dec;26(4):237-43. doi: 10.1177/0891988713500587. Epub 2013 Aug 22.
To describe the prevalence and clinical determinants of apathy in elderly nondemented patients with Parkinson's disease (PD) and their relationship to quality of life (QoL).
A total of 106 nondemented elderly patients with PD were examined using the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Starkstein Apathy Scale, Hospital Anxiety and Depression Scale, Beck Depression Inventory-II, and 39-item Parkinson's disease quality of life questionnaire.
Apathy was present in 54% of the studied population. Factors associated with apathy were higher depression scores and a lower daily levodopa equivalent dose. Longer disease duration, higher motor MDS-UPDRS subscore, and higher depression and anxiety scores, but not apathy, were found to be associated with worse QoL.
Although apathy does not seem to be an independent predictor of worse QoL specifically in elderly patients with PD, it remains very relevant, as its presence increases caregiver burden. Both depression and potential dopaminergic treatment underdosing can be properly managed, thus potentially reducing the prevalence and severity of apathy in a proportion of the apathetic patients with PD.
描述非痴呆老年帕金森病（PD）患者中淡漠的患病率和临床决定因素及其与生活质量（QoL）的关系。
使用运动障碍学会统一帕金森病评定量表（MDS-UPDRS）、Starkstein 淡漠量表、医院焦虑和抑郁量表、贝克抑郁量表 II 以及 39 项帕金森病生活质量问卷，对 106 名非痴呆老年 PD 患者进行了检查。
研究人群中存在淡漠的比例为 54%。与淡漠相关的因素是抑郁评分较高和每日左旋多巴等效剂量较低。更长的疾病持续时间、更高的运动 MDS-UPDRS 子评分、更高的抑郁和焦虑评分，但不是淡漠，与较差的 QoL 相关。
尽管淡漠似乎不是老年 PD 患者 QoL 更差的独立预测因素，但它仍然非常重要，因为它的存在会增加照顾者的负担。抑郁和潜在的多巴胺能治疗剂量不足都可以得到适当的管理，从而有可能降低 PD 患者中淡漠的发生率和严重程度。
