Tu Xiao-Jing, Hwang Wen-Juh, Ma Hui-Ing, Chang Ling-Hui, Hsu Shih-Pin
Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Department of Neurology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
PLoS One. 2017 Jun 26;12(6):e0178896. doi: 10.1371/journal.pone.0178896. eCollection 2017.
Generic and disease-specific health-related quality of life (HRQoL) instruments may reflect different aspects of lives in patients with Parkinson's disease (PD) and thus be associated with different determinants. We used the same cluster of predictors for the generic and disease-specific HRQoL instruments to examine and compare the determinants of HRQoL.
HRQoL was measured in 92 patients with PD by the 36-item Short-Form Health Survey (SF-36) and the 39-item Parkinson's Disease Questionnaire (PDQ-39). The predictors included demographic and disease characteristics, and motor and non-motor symptoms. Multiple regression analyses were used to identify HRQoL determinants.
Depressive symptoms and motor difficulties of daily living were the first two significant determinants for both instruments. The other significant determinant for the SF-36 was fatigue and non-motor difficulties of daily living, and for the PDQ-39 was motor signs of PD.
The results suggest the importance of the evaluation and intervention focused on depressive symptoms and motor difficulties of daily living in patients with PD. In addition, the SF-36 seems more related to non-motor symptoms, while the PDQ-39 appears more associated with motor symptoms. This information is important for understanding results from these two instruments and for choosing which to use.
通用型和疾病特异性的健康相关生活质量（HRQoL）工具可能反映帕金森病（PD）患者生活的不同方面，因此与不同的决定因素相关。我们对通用型和疾病特异性HRQoL工具使用相同的预测因素集群，以检查和比较HRQoL的决定因素。
采用36项简短健康调查（SF - 36）和39项帕金森病问卷（PDQ - 39）对92例PD患者的HRQoL进行测量。预测因素包括人口统计学和疾病特征，以及运动和非运动症状。采用多元回归分析确定HRQoL的决定因素。
抑郁症状和日常生活中的运动困难是两种工具的前两个重要决定因素。SF - 36的另一个重要决定因素是疲劳和日常生活中的非运动困难，而PDQ - 39的是PD的运动体征。
结果表明对PD患者抑郁症状和日常生活运动困难进行评估和干预的重要性。此外，SF - 36似乎与非运动症状更相关，而PDQ - 39似乎与运动症状更相关。这些信息对于理解这两种工具的结果以及选择使用哪种工具很重要。
