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在接受利托那韦增强型达芦那韦治疗的患者中，关节腔内注射曲安奈德后发生医源性库欣综合征。

Iatrogenic Cushing syndrome after intra-articular triamcinolone in a patient receiving ritonavir-boosted darunavir.

作者信息

Hall Jill J, Hughes Christine A, Foisy Michelle M, Houston Stan, Shafran Stephen

机构信息

Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.

出版信息

Int J STD AIDS. 2013 Sep;24(9):748-52. doi: 10.1177/0956462413480723. Epub 2013 Jul 8.

DOI:10.1177/0956462413480723
PMID:23970582
Abstract

Drug interactions involving human immunodeficiency virus protease inhibitors are common due to their inhibition of the cytochrome P450 3A4 isoenzyme. We describe the case of an HIV-infected patient treated with ritonavir-boosted darunavir who developed cushingoid features following an intra-articular injection of triamcinolone acetate. We review the probable mechanism for this interaction and describe similar cases of Cushing syndrome in patients receiving concomitant ritonavir and triamcinolone.

摘要

由于人类免疫缺陷病毒蛋白酶抑制剂会抑制细胞色素P450 3A4同工酶，因此涉及此类药物的药物相互作用很常见。我们描述了一名接受利托那韦增强型达芦那韦治疗的HIV感染患者的病例，该患者在关节腔内注射醋酸曲安奈德后出现了库欣样特征。我们回顾了这种相互作用的可能机制，并描述了接受利托那韦和曲安奈德联合治疗的患者中类似的库欣综合征病例。

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