Kenyon Chris, Colebunders Robert, Buve Anne, Hens Niel
HIV/STD Unit, Institute of Tropical Medicine, University of Antwerp, Antwerp, Belgium.
Int J STD AIDS. 2013 Oct;24(10):804-12. doi: 10.1177/0956462413482810. Epub 2013 Jul 19.
Whilst much is known about the individual-level risk factors for herpes simplex virus 2 (HSV-2) infection, little is known about why only some populations develop generalized HSV-2 epidemics. This study aims to assess the extent to which partner-concurrency (a factor which operates at both the partnership- and network-level) may be responsible. We utilized multivariate logistic regression to analyse the relationship between HSV-2 seropositivity and potential risk factors in data from a representative cross-sectional survey of 14-24 year olds from a township in South Africa conducted in 1999. The overall prevalence of HSV-2 was 53.3% amongst women and 17% amongst men. For men, four factors remained significantly associated with HSV-2 infection in the multivariate regression analysis: total number of sex acts, being a migrant labourer, Zulu ethnicity and being human immunodeficiency virus (HIV) positive. For women, eight factors were associated with HSV-2 infection: increasing age, partner-concurrency (having a partner who had other partners), an older partner, total number of sex acts, using hormonal contraception, Xhosa ethnicity, syphilis seropositivity and being HIV positive. We conclude that partner-concurrency is associated with increased HSV-2 seropositivity in women.
虽然我们对单纯疱疹病毒2型（HSV - 2）感染的个体层面风险因素了解甚多，但对于为何只有部分人群会出现HSV - 2全身性流行却知之甚少。本研究旨在评估伴侣并发情况（这是一个在伴侣关系和网络层面都起作用的因素）对此可能产生影响的程度。我们利用多变量逻辑回归分析了1999年在南非一个乡镇对14至24岁人群进行的代表性横断面调查数据中HSV - 2血清阳性与潜在风险因素之间的关系。HSV - 2在女性中的总体患病率为53.3%，在男性中为17%。在多变量回归分析中，对于男性，有四个因素与HSV - 2感染仍显著相关：性行为总数、身为流动劳工、祖鲁族裔以及人类免疫缺陷病毒（HIV）呈阳性。对于女性，有八个因素与HSV - 2感染相关：年龄增长、伴侣并发情况（伴侣有其他伴侣）、伴侣年龄较大、性行为总数、使用激素避孕、科萨族裔、梅毒血清阳性以及HIV呈阳性。我们得出结论，伴侣并发情况与女性HSV - 2血清阳性率增加有关。
