Rodgers S, Murgatroyd M, Perez K, Kingston M, Lee V
Manchester Centre for Sexual Health, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
Int J STD AIDS. 2014 Feb;25(2):145-7. doi: 10.1177/0956462413495822. Epub 2013 Jul 19.
Neisseria gonorrhoeae has progressively developed reduced sensitivity to different classes of antibiotics. The British Association for Sexual Health and HIV (BASHH) updated guidelines for the diagnosis and management of gonorrhoea in 2011. New recommendations include an increased dose of ceftriaxone with adjuvant use of azithromycin, as well as test of cure (TOC) in all cases. We present an audit of adherence to new antibiotic prescribing guidelines as well as TOC uptake in an inner city genitourinary medicine clinic. Among the 271 (242 male, 29 female) patients included, 96% (n = 260) received the new first-line treatment. Test of cure uptake was found to be suboptimal at 55% (n = 149) with the majority (67%) of these taking place within 20 days of treatment. The new first-line treatment for gonorrhoea is feasible and generally accepted by patients. However the TOC uptake is low, emphasising the need for robust follow-up and recall policies. Further study is required into the optimal timing for TOC.
淋病奈瑟菌对不同种类抗生素的敏感性已逐渐降低。英国性健康与艾滋病协会(BASHH)于2011年更新了淋病诊断和管理指南。新建议包括增加头孢曲松剂量并辅助使用阿奇霉素,以及对所有病例进行治愈检测(TOC)。我们对市中心一家性传播疾病诊所遵循新抗生素处方指南的情况以及TOC的采用情况进行了审核。在纳入的271名患者(242名男性,29名女性)中,96%(n = 260)接受了新的一线治疗。发现治愈检测的采用率不理想,为55%(n = 149),其中大多数(67%)在治疗后20天内进行。淋病的新一线治疗是可行的,并且患者普遍接受。然而,TOC的采用率较低,这突出了强有力的随访和召回政策的必要性。需要进一步研究TOC的最佳时机。