Janssen M A M, Bertens D, Kessels L, Kessels R P C, Koopmans P P
Department of Medical Psychology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Int J STD AIDS. 2013 May;24(5):387-91. doi: 10.1177/0956462412472802. Epub 2013 Jun 18.
The objective of this study was to examine and relate both cognitive functioning and psychological wellbeing in Dutch HIV-1-infected patients (n = 30) in comparison with a matched healthy control group (n = 30), taking symptom validity into account. Significant differences in performance between patients and controls were found in the domain Working memory (P = 0.036), but not in the other cognitive domains. There was a significant difference in all dimensions of the psychological wellbeing scale, measured with the SCL-90-R (P values between 0.002 and 0.023), except for agoraphobia, cognitive performance difficulty and sleep disturbances. No correlations were found between the performance on the Working memory domain and wellbeing. Future research should focus on unravelling the underlying mechanisms of neurocognitive dysfunction further using neuropsychological tests, including a symptom validity test in combination with neuroimaging techniques in larger samples.
本研究的目的是，在考虑症状效度的情况下，对30名荷兰HIV-1感染患者与30名匹配的健康对照组进行比较，以检验并关联他们的认知功能和心理健康状况。患者与对照组在工作记忆领域的表现存在显著差异（P = 0.036），但在其他认知领域则无差异。使用SCL-90-R量表测量的心理健康量表的所有维度均存在显著差异（P值在0.002至0.023之间），除了广场恐惧症、认知表现困难和睡眠障碍。工作记忆领域的表现与幸福感之间未发现相关性。未来的研究应进一步聚焦于，运用神经心理学测试，包括在更大样本中结合神经影像技术进行症状效度测试，来揭示神经认知功能障碍的潜在机制。
