The Second Clinical College, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Evid Based Complement Alternat Med. 2013;2013:545707. doi: 10.1155/2013/545707. Epub 2013 Jul 21.
Objective. To observe effects of the thermal stimulation by moxibustion at different temperatures on cardiac function in brachycardia rat model and on mast cells in the local site of moxibustion at the Ximen Acupoint and to compare the differences of the effects of moxibustion at different temperatures. Method. Establish the brachycardia rat model with propranolol and observe effects of the thermal stimulation by moxibustion at different temperatures (38°C and 46°C). Results. The thermal stimulation by moxibustion at 2 temperatures may increase HR, MAP, LVSP, and +dp/dtmax and reduce t-dp/dtmax in brachycardia rats; the 46°C moxibustion group shows greater regulating effects on cardiac function in rats than that in the 38°C moxibustion group (P < 0.05). The thermal stimulation by moxibustion at 2 temperatures may promote degranulation of mast cells in the local site of moxibustion at the Ximen Acupoint; the degranulation rate in the 46°C moxibustion group is higher than that in the 38°C moxibustion group (P < 0.05). Conclusion. There is a certain association between the effect on the target organ and the effect in the local site of moxibustion. The moxibustion effect possibly resulted from local mast cells degranulation and different thermoreceptors activated by the thermal stimulation at different temperatures.
目的。观察不同温度艾灸对缓慢性心律失常大鼠心功能及西门穴局部灸点肥大细胞的影响，并比较不同温度艾灸的效应差异。方法。采用心得安造模法建立缓慢性心律失常大鼠模型，观察不同温度（38℃和 46℃）艾灸的温热刺激作用。结果。两种温度的艾灸温热刺激均可增加缓慢性心律失常大鼠的心率、平均动脉压、左心室收缩压、左心室收缩压最大上升速率和降低左心室收缩压最大下降速率；46℃艾灸组对大鼠心功能的调节作用优于 38℃艾灸组（P<0.05）。两种温度的艾灸温热刺激均可促进西门穴局部灸点肥大细胞脱颗粒；46℃艾灸组的脱颗粒率高于 38℃艾灸组（P<0.05）。结论。艾灸对靶器官的作用与对局部灸点的作用之间存在一定的关联。艾灸效应可能是由局部肥大细胞脱颗粒和不同温度的温热刺激激活的不同热敏感受器引起的。
