Demir B Cetinkaya, Atalay M A, Ozerkan K, Doster Y, Ocakoglu G, Kucukkomurcu S
Department of Obstetrics and Gynecology, Faculty of Medicine, Uludag University, Nilufer, Bursa, Turkey.
Clin Exp Obstet Gynecol. 2013;40(2):261-7.
To evaluate the role of adiponectin and visfatin in the pathophysiology of pre-eclampsia (PE) and how their concentrations correlate with the severity of the disease and neonatal outcomes.
A prospective case-control study was carried out in 52 preeclamptic and 28 healthy pregnant women during the third trimester. The maternal plasma concentrations of adiponectin and visfatin were determined. Neonatal outcomes were also recorded.
Mean maternal plasma adiponectin concentrations in healthy pregnant women did not differ significantly from those of mild PE and severe PE groups. The plasma adiponectin levels of PE patients with small for gestational age (SGA) and those without SGA did not differ significantly, but the median plasma visfatin concentration of patients with SGA fetus was significantly higher if the patient was preeclamptic (p = 0.036).
The severity of preeclampsia did not change the plasma levels of adiponectin and visfatin, but the median plasma visfatin concentration of patients with SGA fetuses were significantly higher if the patient was preeclamptic. Altered levels of adipocytokines strongly imply that the regulation of adipocytokines in PE is different and more complex compared to that in healthy pregnancy.
评估脂联素和内脂素在子痫前期（PE）病理生理学中的作用，以及它们的浓度与疾病严重程度和新生儿结局的相关性。
对52例子痫前期孕妇和28例健康孕妇在孕晚期进行了一项前瞻性病例对照研究。测定了孕妇血浆中脂联素和内脂素的浓度。还记录了新生儿结局。
健康孕妇的平均血浆脂联素浓度与轻度PE组和重度PE组相比无显著差异。小于胎龄儿（SGA）的PE患者和非SGA的PE患者的血浆脂联素水平无显著差异，但如果患者为子痫前期，SGA胎儿患者的血浆内脂素中位数浓度显著更高（p = 0.036）。
子痫前期的严重程度并未改变脂联素和内脂素的血浆水平，但如果患者为子痫前期，SGA胎儿患者的血浆内脂素中位数浓度显著更高。脂肪细胞因子水平的改变强烈表明，与健康妊娠相比，子痫前期中脂肪细胞因子的调节不同且更复杂。
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