Allergy, Immunology and Rheumatology Unit, Division of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Expert Rev Clin Immunol. 2013 Aug;9(8):751-60. doi: 10.1586/1744666X.2013.816493.
Atopic dermatitis (AD) is a highly prevalent allergic skin disease that affects children worldwide. Epidemiological, clinical and basic immunological studies have suggested an association between vitamin D (VD) deficiency and the development of AD and other allergic diseases. Low levels of VD, a pleiotropic hormone that has widespread effects on the immune system and skin integrity, appear to be inversely correlated with AD severity, and VD deficiency at birth is associated with higher risk of developing AD. Recent randomized trials have reported inconsistent, but still promising, results on whether VD supplementation may improve AD severity. The apparent differences are likely due to small samples, different regimens and different patient populations. The mechanisms underlying this potential improvement in AD severity remain under investigation.
特应性皮炎（AD）是一种在全世界儿童中普遍存在的高度过敏性皮肤疾病。流行病学、临床和基础免疫学研究表明，维生素 D（VD）缺乏与 AD 和其他过敏性疾病的发生有关。VD 是一种具有广泛的免疫和皮肤完整性作用的多效激素，其水平较低与 AD 严重程度呈负相关，出生时 VD 缺乏与更高的 AD 发病风险相关。最近的随机试验报告了关于 VD 补充是否可能改善 AD 严重程度的不一致但仍有希望的结果。这种 AD 严重程度潜在改善的明显差异可能是由于样本量小、方案不同和患者人群不同所致。其潜在的改善机制仍在研究中。
