Section of Dermatology, Department of Biomedical Science and Human Oncology, University of Bari, 11 Piazza Giulio Cesare, 70124 Bari, Italy.
Section of Dermatology, Vito Fazzi Hospital, Piazza Filippo Muratore, 73100 Lecce, Italy.
J Immunol Res. 2015;2015:257879. doi: 10.1155/2015/257879. Epub 2015 Apr 20.
Vitamin D features immunomodulatory effects on both the innate and adaptive immune systems, which may explain the growing evidence connecting vitamin D to allergic diseases. A wealth of studies describing a beneficial effect of vitamin D on atopic dermatitis (AD) prevalence and severity are known. However, observations linking high vitamin D levels to an increased risk of developing AD have also been published, effectively creating a controversy. In this paper, we review the existing literature on the association between AD and vitamin D levels, focusing on childhood. As of today, the role of vitamin D in AD is far from clear; additional studies are particularly needed in order to confirm the promising therapeutic role of vitamin D supplementation in childhood AD.
维生素 D 对先天和适应性免疫系统具有免疫调节作用，这可以解释越来越多的证据将维生素 D 与过敏性疾病联系起来。已知有大量研究描述了维生素 D 对特应性皮炎 (AD) 患病率和严重程度的有益影响。然而，也有研究观察到高维生素 D 水平与 AD 发病风险增加有关，这实际上引发了争议。在本文中，我们回顾了现有的关于 AD 和维生素 D 水平之间关联的文献，重点是儿童时期。迄今为止，维生素 D 在 AD 中的作用还远不清楚；需要进一步的研究来证实维生素 D 补充在儿童 AD 中的有前途的治疗作用。
