Gahl W A, Schneider J A, Schulman J D, Thoene J G, Reed G F
Human Genetics Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
Pediatr Nephrol. 1990 Mar;4(2):129-35. doi: 10.1007/BF00858823.
The predicted reciprocal creatinine at age 10 years (PRC10), a parameter of renal function based upon the linear relationship between reciprocal serum creatinine and age, incorporates age, serum creatinine, and rate of renal deterioration into a single term. PRC10 measurements were employed to assess renal function in children with nephropathic cystinosis treated with oral cysteamine, a cystine-depleting agent. In 71 children receiving oral cysteamine for at least 1 year, PRC10 decreased linearly with initial serum creatinine concentration. This indicated that, although established renal damage in cystinosis was irreversible, early intervention with cysteamine therapy could favorably alter the rate of glomerular deterioration. In other analyses, mean PRC10 was shown to increase with duration of cysteamine therapy and extent of leukocyte cystine depletion. The predicted reciprocal creatinine value at a certain age can be useful in analyzing the effects of therapeutic intervention in a disease with a relatively uniform rate of renal deterioration.
10岁时预测的肌酐倒数（PRC10）是基于血清肌酐倒数与年龄之间的线性关系得出的肾功能参数，它将年龄、血清肌酐和肾功能恶化速率整合为一个单一指标。PRC10测量值被用于评估接受口服半胱胺（一种耗竭胱氨酸的药物）治疗的肾病性胱氨酸病患儿的肾功能。在71名接受口服半胱胺至少1年的儿童中，PRC10随初始血清肌酐浓度呈线性下降。这表明，尽管胱氨酸病中已确立的肾损伤是不可逆的，但早期采用半胱胺治疗可有利地改变肾小球恶化速率。在其他分析中，平均PRC10显示随半胱胺治疗持续时间和白细胞胱氨酸耗竭程度的增加而升高。在一种肾功能恶化速率相对一致的疾病中，特定年龄的预测肌酐倒数值有助于分析治疗干预的效果。
