Fulton Amy J, Nemec Ana, Murphy Brian G, Kass Philip H, Verstraete Frank J M
William R. Pritchard Veterinary Medical Teaching Hospital Small Animal Clinic, School of Veterinary Medicine, University of California-Davis, CA 95616, USA.
J Am Vet Med Assoc. 2013 Sep 1;243(5):696-702. doi: 10.2460/javma.243.5.696.
To identify risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma (OSCC) that were and were not treated with curative-intent surgery.
Retrospective case series.
31 dogs with OSCC.
Medical records for dogs with OSCC that were not treated, or were treated with curative-intent surgery only between January 1990 and December 2010 were reviewed. For each dog, data regarding signalment, clinical stage, treatment, tumor recurrence, and survival time were obtained from the medical record, and archived biopsy specimens were evaluated to identify the histologic subtype of the tumor and extent of tumor-associated inflammation (TAI), perineural invasion (PNI), and lymphovascular invasion (LVI).
Risk of death for the 21 dogs with OSCC that were surgically treated was decreased 91.4% (hazard ratio, 0.086; 95% confidence interval, 0.002 to 0.150), compared with that for the 10 dogs with OSCC that were not treated. The 1-year survival rate was 93.5% and 0% for dogs that were and were not surgically treated, respectively. Risk of death increased significantly with increasing TAI and increasing risk score (combination of TAI, PNI, and LVI). Tumor location, clinical stage, and histologic subtype were not associated with survival time.
Results indicated that the prognosis for dogs with OSCC was excellent following surgical excision of the tumor. Risk of death increased with increasing TAI, and combining TAI, PNI, and LVI into a single risk score may be a useful prognostic indicator for dogs with OSCC.
确定未接受和接受了根治性手术治疗的非扁桃体口腔鳞状细胞癌（OSCC）犬的生存相关危险因素。
回顾性病例系列研究。
31只患有OSCC的犬。
回顾了1990年1月至2010年12月期间未接受治疗或仅接受了根治性手术治疗的OSCC犬的病历。从病历中获取每只犬的信号、临床分期、治疗、肿瘤复发和生存时间等数据，并对存档的活检标本进行评估，以确定肿瘤的组织学亚型以及肿瘤相关炎症（TAI）、神经周围浸润（PNI）和淋巴管浸润（LVI）的程度。
与10只未接受治疗的OSCC犬相比，21只接受手术治疗的OSCC犬的死亡风险降低了91.4%（风险比，0.086；95%置信区间，0.002至0.150）。接受和未接受手术治疗的犬的1年生存率分别为93.5%和0%。随着TAI增加以及风险评分（TAI、PNI和LVI的组合）增加，死亡风险显著增加。肿瘤位置、临床分期和组织学亚型与生存时间无关。
结果表明，肿瘤手术切除后OSCC犬的预后良好。死亡风险随着TAI增加而增加，将TAI、PNI和LVI合并为单一风险评分可能是OSCC犬有用的预后指标。
