Nemec A, Murphy B, Kass P H, Verstraete F J M
William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA.
J Comp Pathol. 2012 Aug-Oct;147(2-3):111-20. doi: 10.1016/j.jcpa.2011.11.198. Epub 2012 Jan 31.
Several histological subtypes and grades of oral squamous cell carcinoma (SCC) are described in human literature and these subtypes have distinct morphological features and biological behaviour. This retrospective study (1990-2010) included 84 dogs diagnosed with SCC of the oral cavity and oropharynx, excluding the tonsils. Sixty-nine of the SCCs (82.1%) were further diagnosed as conventional SCC (CSCC) (33 [47.8%] well-differentiated, 31 [44.9%] moderately-differentiated and five [7.3%] poorly-differentiated), five (5.95%) each as papillary SCC and basaloid SCC, three (3.6%) as adenosquamous carcinoma and two (2.4%) as spindle cell carcinoma. Compared with the general hospital population, neutered female dogs, dogs aged 10 to <15 years, English springer spaniels and Shetland sheepdogs were overrepresented. The majority (78.1%) of SCCs were proliferative with or without associated ulceration, although no significant association was observed between the gross appearance and different SCC subtypes. 71.4% of SCCs were located in dentate jaws; however, well-differentiated CSCC more often affected the tongue and other non-dentate mucosal surfaces (P=0.0022). No significant association was found between any of the SCC subtypes and tumour-associated inflammation (TAI), perineural and lymphovascular invasion (PNI, LVI), or between gross appearance of the tumour and tumour location, PNI, LVI or TAI or PNI, LVI, TAI and tumour location.
人类文献中描述了几种口腔鳞状细胞癌（SCC）的组织学亚型和分级，这些亚型具有不同的形态特征和生物学行为。这项回顾性研究（1990 - 2010年）纳入了84只被诊断为口腔和口咽SCC的犬，不包括扁桃体。其中69只SCC（82.1%）被进一步诊断为传统SCC（CSCC）（33只[47.8%]高分化，31只[44.9%]中分化，5只[7.3%]低分化），乳头状SCC和基底样SCC各5只（5.95%），腺鳞癌3只（3.6%），梭形细胞癌2只（2.4%）。与普通医院犬群相比，绝育雌性犬、10至<15岁的犬、英国激飞猎犬和设得兰牧羊犬的比例过高。大多数SCC（78.1%）有增殖，伴或不伴有溃疡，尽管大体外观与不同SCC亚型之间未观察到显著关联。71.4%的SCC位于有齿颌骨；然而，高分化CSCC更常累及舌和其他无齿黏膜表面（P = 0.0022）。未发现任何SCC亚型与肿瘤相关炎症（TAI）、神经周和淋巴管浸润（PNI、LVI）之间存在显著关联，也未发现肿瘤大体外观与肿瘤位置、PNI、LVI或TAI，或PNI、LVI、TAI与肿瘤位置之间存在显著关联。
