a Department of Chemistry , Faculty of Science, Jamia Hamdard (Hamdard University) , New Delhi , 110062 , India.
Nat Prod Res. 2013;27(24):2304-10. doi: 10.1080/14786419.2013.828292. Epub 2013 Aug 25.
Two new triterpenoids characterised as 30-normethyl fernen-22-one (capillirone, 1) and hopan-3β-ol (capillirol B, 2), along with two known triterpenoids, 4-α-hydroxyfilican-3-one and 3-β,4-α-dihydroxyfilicane, have been isolated from the ethanolic extract of the fronds of Adiantum capillus-veneris Linn. (Adiantaceae). Compounds 1 and 3 showed significant anti-inflammatory activity with 33.07% (p < 0.01) and 42.30% (p < 0.001) inhibition as compared to indomethacin that exhibited 60.00% (p < 0.001) inhibition after 3 h in the carrageenan-induced hind paw oedema method. Compound 3 showed potent anti-nociceptive activity with 42.37% inhibition as compared to indomethacin that showed 45.34% inhibition in the writhing test.
从凤尾蕨（凤尾蕨科）叶片的乙醇提取物中分离得到了两种新的三萜类化合物，分别为 30-降甲基羊齿-22-酮（capillirone，1）和霍烷-3β-醇（capillirol B，2），以及两种已知的三萜类化合物 4-α-羟基菲坎酮和 3-β,4-α-二羟基菲坎烷。与吲哚美辛相比，化合物 1 和 3 在角叉菜胶诱导的大鼠后爪水肿模型中分别显示出 33.07%（p < 0.01）和 42.30%（p < 0.001）的显著抗炎活性，而吲哚美辛的抑制率为 60.00%（p < 0.001）。在扭体试验中，与吲哚美辛（45.34%）相比，化合物 3 表现出较强的镇痛活性，抑制率为 42.37%。
