Partin Alexander, Hah Zaegyoo, Barry Christopher T, Rubens Deborah J, Parker Kevin J
Department of Electrical and Computer Engineering, University of Rochester, Rochester, New York, USA.
Department of Surgery, University of Rochester Medical Center, Rochester, New York, USA.
Ultrasound Med Biol. 2014 Apr;40(4):685-94. doi: 10.1016/j.ultrasmedbio.2013.05.019. Epub 2013 Aug 22.
We describe a surface-based approach to the generation of shear wave interference patterns, called crawling waves (CrW), within a medium and derive local estimates of biomechanical properties of tissue. In previous experiments, elongated bars operating as vibration sources were used to generate CrW propagation in samples. In the present study, however, a pair of miniature circular vibration sources was applied to the overlying skin to generate the CrW within the medium. The shape and position of the miniature sources make this configuration more applicable for in vivo implementation. A modified ultrasound imaging system is used to display the CrW propagation. A shear speed mapping algorithm is developed using a detailed analysis of the CrW. The proposed setup is applied to several biomaterials including a homogeneous phantom, an inhomogeneous phantom and an ex vivo human liver. The data are analyzed using the mapping algorithm to reveal the biomechanical properties of the biomaterials.
我们描述了一种基于表面的方法，用于在介质中生成称为爬行波（CrW）的剪切波干涉图案，并推导组织生物力学特性的局部估计值。在先前的实验中，使用作为振动源的细长杆在样本中生成CrW传播。然而，在本研究中，一对微型圆形振动源被应用于覆盖的皮肤，以在介质中生成CrW。微型源的形状和位置使这种配置更适用于体内实施。使用改进的超声成像系统来显示CrW传播。通过对CrW的详细分析开发了一种剪切速度映射算法。所提出的设置应用于几种生物材料，包括均匀体模、非均匀体模和离体人肝脏。使用映射算法分析数据以揭示生物材料的生物力学特性。
