Research Department, Eindhoven Cancer Registry/Comprehensive Cancer Centre South, PO Box 231, 5600 Eindhoven, The Netherlands.
Breast. 2013 Oct;22(5):1001-4. doi: 10.1016/j.breast.2013.07.039. Epub 2013 Aug 22.
With modern scalp cooling equipment cytotoxic damage of hair root cells can be prevented in half of the patients with cancer at high risk of alopecia. However, traditionally doubt has existed whether scalp cooling might facilitate hiding and disseminating scalp skin metastases and thus decrease survival. We discuss this risk using frequency data on metastases in breast cancer from observational and autopsy studies and the Munich cancer registry. They showed the incidence of scalp skin metastases to be very low and not differ between scalp-cooled (0.04-1%) and non scalp-cooled (0.03-3%) patients with breast cancer and in need of chemotherapy. We found it rather unlikely that the incidence of scalp skin metastases might increase at all after scalp cooling, whereas a very small proportion of patients receiving chemotherapy are at risk to develop metastases at this site. Scalp cooling can thus safely be offered to patients treated with alopecia-inducing chemotherapy.
使用现代头皮冷却设备，有一半高脱发风险的癌症患者可以预防毛囊细胞的细胞毒性损伤。然而，传统上一直存在疑问，即头皮冷却是否会促进头皮皮肤转移的隐匿和扩散，从而降低存活率。我们使用来自观察性研究和尸检研究以及慕尼黑癌症登记处的乳腺癌转移频率数据来讨论这种风险。结果显示，头皮皮肤转移的发生率非常低，在需要化疗的头皮冷却（0.04-1%）和非头皮冷却（0.03-3%）的乳腺癌患者之间没有差异。我们发现，头皮冷却后头皮皮肤转移的发生率增加的可能性很小，而接受化疗的患者中只有一小部分有在此部位发生转移的风险。因此，头皮冷却可以安全地提供给接受脱发诱导化疗的患者。
