Lauritzen Hilde B, Larose Tricia L, Øien Torbjørn, Sandanger Torkjel M, Odland Jon Ø, van de Bor Margot, Jacobsen Geir W
Department of Public Health and General Practice, Norwegian University for Science and Technology, Trondheim, Norway.
Department of Community Medicine, University of Tromsø - The Arctic University of Norway, Tromsø, Norway.
Pediatr Res. 2017 Jan;81(1-1):33-42. doi: 10.1038/pr.2016.187. Epub 2016 Sep 22.
The associations between prenatal exposure to endocrine disruptive chemicals (EDCs) and fetal growth are inconsistent, and few studies have considered small-for-gestational-age (SGA) birth as an outcome. Our current study of Scandinavian parous women aimed to address these inconsistencies and gaps in the literature.
This case-cohort study included 424 mother-child pairs who participated in a prospective, multi-center study of parous women in Norway (Trondheim and Bergen) and Sweden (Uppsala). We used linear and logistic regression with 95% confidence intervals (CIs) to analyze the associations between two perfluoroalkyl substances (PFASs) and five organochlorines (OCs) from early second trimester and indices of fetal growth.
Among Swedish women, prenatal exposure to perfluorooctanoate (PFOA), polychlorinated biphenyl (PCB) 153 and hexachlorobenzene (HCB) were associated with higher odds for SGA birth. We found stronger associations among Swedish male offspring. In the Norwegian cohort, we found no significant associations between EDC exposure and indices of fetal growth.
Some populations may be more vulnerable to EDCs, possibly due to differences in exposure levels, exposure sources and/or modifiable lifestyle factors. Male offspring may be more vulnerable to endocrine disruption.
产前暴露于内分泌干扰化学物（EDCs）与胎儿生长之间的关联并不一致，而且很少有研究将小于胎龄儿（SGA）出生作为一项结局进行考量。我们目前针对斯堪的纳维亚地区经产妇开展的研究旨在解决文献中的这些不一致之处和空白。
这项病例队列研究纳入了424对母婴，这些母婴参与了一项针对挪威（特隆赫姆和卑尔根）和瑞典（乌普萨拉）经产妇的前瞻性多中心研究。我们使用95%置信区间（CIs）的线性回归和逻辑回归来分析孕中期早期两种全氟烷基物质（PFASs）和五种有机氯（OCs）与胎儿生长指标之间的关联。
在瑞典女性中，产前暴露于全氟辛酸（PFOA）、多氯联苯（PCB）153和六氯苯（HCB）与SGA出生几率较高相关。我们发现瑞典男性后代中的关联更强。在挪威队列中，我们未发现EDC暴露与胎儿生长指标之间存在显著关联。
一些人群可能对EDCs更为敏感，这可能是由于暴露水平、暴露源和/或可改变的生活方式因素存在差异。男性后代可能对内分泌干扰更为敏感。
