Mortimer A M, Lund C E, McKenna P J
University of Leeds.
Br J Psychiatry. 1990 Jul;157:41-9. doi: 10.1192/bjp.157.1.41.
Two studies are reported. In the first, of 62 schizophrenic patients, no correlation between negative symptom scores (rated blindly) and any measure of positive symptoms was found. This independence was confirmed by factor and cluster analyses, which left the question of a third 'disorganisation' class of schizophrenic symptoms open. In the second study, of 80 patients, formal thought disorder separated unequivocally into 'positive formal thought disorder' and 'alogia' syndromes on the basis of correlations with positive and negative symptoms. Catatonic motor disorder also showed evidence of a corresponding positive: negative division, although this only emerged when severity or chronicity of illness was controlled for. Cognitive impairment showed a broad range of affiliations and its particular correlation with negative symptoms was perhaps artefactual.
报告了两项研究。第一项研究中，在62名精神分裂症患者中，未发现阴性症状评分（盲法评定）与任何阳性症状指标之间存在相关性。因子分析和聚类分析证实了这种独立性，这使得精神分裂症症状的第三种“紊乱”类别问题悬而未决。在第二项研究中，在80名患者中，基于与阳性和阴性症状的相关性，形式思维障碍明确分为“阳性形式思维障碍”和“言语贫乏”综合征。紧张性运动障碍也显示出相应的阳性：阴性划分的证据，尽管这仅在控制疾病的严重程度或慢性病程时才出现。认知障碍显示出广泛的关联，其与阴性症状的特定相关性可能是人为造成的。
