Parker G, Hadzi-Pavlovic D, Boyce P, Wilhelm K, Brodaty H, Mitchell P, Hickie I, Eyers K
University of New South Wales, Australia.
Br J Psychiatry. 1990 Jul;157:55-65. doi: 10.1192/bjp.157.1.55.
The possibility that separation of a categorical depressive disease ('melancholia') from remaining depressive disorders can be improved by assessment of mental state signs was examined in patients treated by representative Sydney psychiatrists and patients referred to a specialised mood disorders unit. A set of signs, principally assessing retardation, was derived within the two samples by principal-components and latent-class analyses. Scores were significantly correlated with clinical, DSM-III, and RDC diagnoses, and appeared independent of severity, suggesting that melancholia can be defined phenomenologically. Scores were also associated with several 'validating' factors. Comparative analyses of a refined list of melancholia symptoms suggested that ratings of defined signs are likely to have greater capacity than symptom ratings to differentiate melancholia from residual depressive disorders.
在由悉尼代表性精神科医生治疗的患者以及被转诊至专业情绪障碍科室的患者中，研究了通过评估精神状态体征来改善将分类性抑郁疾病（“忧郁症”）与其他抑郁障碍区分开来的可能性。通过主成分分析和潜在类别分析在两个样本中得出了一组主要用于评估迟缓的体征。这些体征得分与临床诊断、《精神疾病诊断与统计手册》第三版（DSM-III）诊断以及研究诊断标准（RDC）诊断显著相关，且似乎与严重程度无关，这表明忧郁症可以从现象学角度进行定义。这些得分还与几个“验证性”因素相关。对忧郁症症状细化列表的比较分析表明，与症状评分相比，对明确体征的评级可能更有能力区分忧郁症与残留性抑郁障碍。
