State Key Laboratory on Integrated Optoelectronics , College of Electronic Science and Engineering, Jilin University, Changchun 130012, China.
Colloids Surf B Biointerfaces. 2013 Dec 1;112:128-33. doi: 10.1016/j.colsurfb.2013.07.020. Epub 2013 Jul 17.
A graphene oxide (GO)-based multifunctional hybrid has been developed for loading and delivery of anticancer drugs. The GO was functionalized by magnetic/fluorescent SiO2 microsphere via an amidation process. Doxorubicin (DOX) was chosen as a model drug to be loaded onto the GO via π-π stacking and hydrophobic interaction. The loading capacities of DOX to the GO-based magnetic fluorescent hybrids were investigated. The release profiles of DOX from the hybrids were depicted. The fluorescence images of the GO-based magnetic fluorescent hybrids indicated that the hybrids would be an effective drug carrier and a potential optical imaging tool. The application of the developed GO-based magnetic fluorescent hybrids for HepG2 cells demonstrated an excellent therapeutic effect of the DOX loaded hybrids to the target tumor.
已开发出一种基于氧化石墨烯（GO）的多功能杂化材料，用于负载和输送抗癌药物。GO 通过酰胺化过程功能化磁性/荧光 SiO2 微球。选择阿霉素（DOX）作为模型药物，通过π-π 堆积和疏水相互作用加载到 GO 上。研究了 DOX 对基于 GO 的磁性荧光杂化物的负载能力。描绘了 DOX 从杂化物中的释放曲线。基于 GO 的磁性荧光杂化物的荧光图像表明，该杂化物将是一种有效的药物载体和潜在的光学成像工具。所开发的基于 GO 的磁性荧光杂化物在 HepG2 细胞中的应用表明，负载 DOX 的杂化物对靶肿瘤具有优异的治疗效果。
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