Department of Cardiology & Molecular Imaging Program; Xijing Hospital; Fourth Military Medical University; Xi'an, PR China.
Organogenesis. 2013 Jul-Sep;9(3):121-4. doi: 10.4161/org.25586. Epub 2013 Jul 3.
Cell-based therapy has emerged to be a promising strategy for alleviating the heavy burden of ischemic cardiovascular disease for nearly two decades, despite a variety of pending questions about its availability and efficacy. One question is whether and how the cells behave for regeneration in vivo, which could be limited or potentiated by the inflammatory microenvironment following myocardial infarction or critical limb ischemia. To this end, we hypothesize that the "adaptive inflammatory microenvironment" is pertinent to the cell-based regeneration, and make a brief comment on it based upon recent evidence.
细胞治疗作为一种有前途的策略，近二十年来已经出现，旨在缓解缺血性心血管疾病的沉重负担，尽管关于其可用性和疗效仍存在许多悬而未决的问题。其中一个问题是细胞在体内是否以及如何进行再生，这可能受到心肌梗死或严重肢体缺血后炎症微环境的限制或增强。为此，我们假设“适应性炎症微环境”与基于细胞的再生有关，并根据最近的证据对此进行简要评论。
