Bayer M
Department of Pediatrics, Faculty of Medicine in Hradec Králové, Charles University and University Hospital Hradec Králové, Sokolská 581, 500 05, Hradec Králové, Czech Republic,
Osteoporos Int. 2014 Feb;25(2):729-36. doi: 10.1007/s00198-013-2485-4. Epub 2013 Aug 22.
The aim of this study was to assess the relationships between both a marker of bone formation and a marker of bone turnover and age, sex, and pubertal stage in a group (n = 439) of healthy children and adolescents. These reference data should be instrumental in interpretation of results.
The skeletal system has high metabolic activity. In children, bone markers may be useful in diagnostics and treatment management of skeletal diseases but there could be difficulties with interpretation of results. Compared with adults, children have elevated bone marker levels due to high skeletal growth velocity and rapid bone turnover. Thus, valid age- and sex-specific reference data should be obtained for each pediatric population living in a particular climate and with a similar lifestyle. The aim of this study was to assess the relationships between both a marker of bone formation (procollagen type I N-terminal propeptide [PINP]) and a marker of bone turnover (osteocalcin [OC]) and age, sex, and pubertal stage in a group of healthy children and adolescents.
Four hundred thirty-nine healthy Caucasian children participated. Their height, weight, and pubertal stage were recorded. Fasting PINP and OC were measured using a morning blood sample.
The highest levels of PINP were observed during the first year of life. There is no OC postnatal peak, but levels are higher than the adult reference interval throughout childhood. OC peaks with the pubertal growth spurt at second-third Tanner stage of breast development in girls and at second-third Tanner stage of genital development in boys. PINP peaks during second-third Tanner stage of breast development in girls and at third Tanner stage of genital development in boys.
This study provides reference data for OC and PINP in healthy Caucasian children from a Central European population.
本研究的目的是评估一组（n = 439）健康儿童和青少年中骨形成标志物和骨转换标志物与年龄、性别及青春期阶段之间的关系。这些参考数据应有助于结果的解读。
骨骼系统具有高代谢活性。在儿童中，骨标志物可能有助于骨骼疾病的诊断和治疗管理，但结果解读可能存在困难。与成年人相比，由于骨骼生长速度快和骨转换迅速，儿童的骨标志物水平升高。因此，对于生活在特定气候且生活方式相似的每个儿科人群，应获取有效的年龄和性别特异性参考数据。本研究的目的是评估一组健康儿童和青少年中骨形成标志物（I型前胶原N端前肽[PINP]）和骨转换标志物（骨钙素[OC]）与年龄、性别及青春期阶段之间的关系。
439名健康的白种儿童参与研究。记录他们的身高、体重和青春期阶段。使用早晨采集的血样测量空腹PINP和OC。
PINP水平在出生后第一年最高。OC没有产后峰值，但在整个儿童期水平高于成人参考区间。OC在女孩乳房发育的坦纳第二至第三阶段和男孩生殖器发育的坦纳第二至第三阶段的青春期生长突增时达到峰值。PINP在女孩乳房发育的坦纳第二至第三阶段和男孩生殖器发育的坦纳第三阶段达到峰值。
本研究为来自中欧人群的健康白种儿童的OC和PINP提供了参考数据。
