Benoist Gregoire, Dossier Claire, Elmaleh Monique, Dauger Stephane
Department of Paediatric, Hôpital Ambroise Paré, AP-HP, University of Versailles Saint-Quentin-en-Yvelines, Boulogne, France.
BMJ Case Rep. 2013 Aug 23;2013:bcr2013010110. doi: 10.1136/bcr-2013-010110.
A 14-year-old girl was admitted to the emergency department for repeated seizures with no fever. High blood pressure at admission was ascribed to the status epilepticus. Seizure recurrence promoted transfer to the paediatric intensive care unit. The MRI visualised bilateral, subcortical, white-matter lesions in the parietal and occipital lobes suggesting posterior reversible encephalopathy syndrome (PRES). Continuous nicardipine infusion corrected the hypertension and neurological manifestations within a few hours. The diagnostic workup showed right renal artery stenosis. Blood pressure returned to normal values for age after right nephrectomy. She was discharged home without treatment. She had no residual neurological impairments. This case highlights the risk of misinterpreting sustained hypertension in children with repeated seizures. We briefly review paediatric PRES, which is rare as compared to adults. Increased awareness among critical care physicians, together with greater availability of cerebral MRI, is decreasing the time to diagnosis.
一名14岁女孩因反复癫痫发作且无发热症状被收入急诊科。入院时的高血压归因于癫痫持续状态。癫痫复发促使其转至儿科重症监护病房。磁共振成像(MRI)显示双侧顶叶和枕叶皮质下白质病变,提示后部可逆性脑病综合征(PRES)。持续静脉输注尼卡地平在数小时内纠正了高血压及神经学表现。诊断检查显示右肾动脉狭窄。右肾切除术后血压恢复至该年龄的正常水平。她未经治疗出院回家。她没有遗留神经功能障碍。该病例强调了在反复癫痫发作的儿童中误判持续性高血压的风险。我们简要回顾了儿科PRES,与成人相比其较为罕见。重症监护医生的认识提高,以及脑部MRI检查的可及性增加,正在缩短诊断时间。