Nightingale Sam, Wood Chris, Ainsworth Jonathan
Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.
BMJ Case Rep. 2012 Jun 25;2012:bcr0120125647. doi: 10.1136/bcr.01.2012.5647.
Posterior reversible encephalopathy syndrome (PRES) is often associated with hypertension, however recent advances in the understanding of this condition have shown that endothelial dysfunction is responsible for much of the pathogenesis and the condition can occur in the absence of hypertension. This case describes a 32-year-old lady with untreated HIV infection who developed PRES at a normal blood pressure and without opportunistic infection or other conditions known to precipitate PRES. HIV, particularly when untreated, is associated with endothelial dysfunction and this may have been sufficient to cause PRES in this patient. To our knowledge this is the first case to describe PRES in HIV without uncontrolled hypertension, sepsis or other precipitating cause.
后部可逆性脑病综合征（PRES）常与高血压相关，然而，对这种病症认识的最新进展表明，内皮功能障碍在很大程度上是其发病机制的原因，并且该病症可在无高血压的情况下发生。本病例描述了一名32岁未接受治疗的HIV感染女性，她在血压正常且无机会性感染或其他已知可引发PRES的情况下发生了PRES。HIV，尤其是未经治疗时，与内皮功能障碍有关，这可能足以导致该患者发生PRES。据我们所知，这是首例描述在无高血压失控、败血症或其他诱发原因的情况下HIV患者发生PRES的病例。
