胆固醇代谢调控的细胞与分子基础研究进展
Discovery of the cellular and molecular basis of cholesterol control.
机构信息
Department of Molecular and Cell Biology and Howard Hughes Medical Institute, University of California, Berkeley, CA 94720.
出版信息
Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14833-6. doi: 10.1073/pnas.1312967110. Epub 2013 Aug 23.
Abstract
The cellular control of cholesterol metabolism mediated by lipoproteins was first appreciated in pioneering work published in a 1974 PNAS Classic by Michael Brown and Joseph Goldstein. We know from this paper that the LDL binds to a cell surface receptor and dampens the activity of a key enzyme in cholesterol biosynthesis and that a receptor deficiency is responsible for a major genetic cause of hypercholesterolemia and premature atherosclerosis.
摘要
脂蛋白介导的胆固醇代谢的细胞控制最早是在 1974 年发表在《美国国家科学院院刊》（PNAS）经典版上的一篇开创性论文中被认识到的，这篇论文的作者是 Michael Brown 和 Joseph Goldstein。从这篇论文中我们知道，LDL 与细胞表面受体结合，抑制胆固醇生物合成中的关键酶的活性，而受体缺乏是导致高胆固醇血症和早发性动脉粥样硬化的主要遗传原因。
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