Clerc C, Pibouin M, Ruelland A, Legras B, Chevrant-Breton J, Cloarec L
Service de Biochimie A, Hotel-Dieu, Rennes, France.
Clin Chim Acta. 1990 Aug 15;189(2):181-9. doi: 10.1016/0009-8981(90)90090-f.
Concentrations of alpha 1 acid glycoprotein, albumin, transferrin, haptoglobin, immunoglobulins G, A, M and apolipoprotein B were measured in serum and suction blister fluid from a group of individuals presenting a biologically proven inflammatory syndrome, and from a control group. Protein values in suction blister fluid did not change from the 2nd to the 3rd h after the beginning of blister formation. The ratio of the concentration of proteins in blister fluid and serum did not differ significantly between the groups. However, a 25% decrease in blister fluid albumin and a 100% increase in blister fluid alpha 1 acid glycoprotein, recorded in the inflammatory group, were worth noting, since they possibly influence the tissular distribution of some protein-binding drugs. Finally, an inverse relationship was established between the blister fluid/serum concentration ratio and the respective molar mass of each protein.
在一组经生物学证实患有炎症综合征的个体以及一个对照组的血清和抽吸水疱液中，测量了α1酸性糖蛋白、白蛋白、转铁蛋白、触珠蛋白、免疫球蛋白G、A、M和载脂蛋白B的浓度。水疱形成开始后第2至3小时，抽吸水疱液中的蛋白质值没有变化。两组之间水疱液和血清中蛋白质浓度的比值没有显著差异。然而，值得注意的是，炎症组中水疱液白蛋白降低了25%，水疱液α1酸性糖蛋白增加了100%，因为它们可能影响某些蛋白结合药物的组织分布。最后，在水疱液/血清浓度比值与每种蛋白质各自的摩尔质量之间建立了反比关系。
