Chen Hai-Fei, Xu Li-Ping, Luo Zhi-Yong, Yu Zi-Qiang, Li Zheng-Yang, Cui Qing-Ya, Qin Long-Mei, Ren Yong-Ya, Shen Hong-Shi, Tang Jie-Qing, Jin Ling-Juan, Zhu Jing-Jing, Wang Jing, Wang Ke-Yuan, Wu Tian-Qin, Wang Zhao-Yue
Department of Hematology, 100th Hospital of People's Liberation Army, Suzhou, People's Republic of China.
Drug Des Devel Ther. 2013 Aug 13;7:767-70. doi: 10.2147/DDDT.S47718. eCollection 2013.
A 41-year-old male had suffered from gradual hearing loss in his right ear for 2 years. Head computed tomography and magnetic resonance imaging scans showed a neoplasm in the cerebellopontine angle region, which was confirmed by the diagnosis of acoustic neurilemmoma by pathological findings after surgery. Following surgery, he routinely received valproic acid (VPA) to prevent seizures. However, the patient presented with hypofibrinogenemia and cerebral hemorrhage after taking VPA for 12 days. The hypofibrinogenemia recurred when VPA was re-administered. After withdrawal of VPA, his fibrinogen concentration rose to normal within several days. As far as we are aware, this is the first case of cerebral hemorrhage due to VPA to have been reported. Herein, as well as reporting on this case, a mini review of the relevant literature is also presented.
一名41岁男性右耳渐进性听力丧失2年。头部计算机断层扫描和磁共振成像扫描显示桥小脑角区有肿瘤，术后病理结果确诊为听神经鞘瘤。术后，他常规服用丙戊酸（VPA）预防癫痫发作。然而，患者服用VPA 12天后出现低纤维蛋白原血症和脑出血。再次服用VPA时低纤维蛋白原血症复发。停用VPA后，他的纤维蛋白原浓度在数天内恢复正常。据我们所知，这是首例因VPA导致脑出血的病例报告。在此，除了报告该病例外，还对相关文献进行了简要综述。
