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1
How further suppression of virus replication could improve current HBV treatment.进一步抑制病毒复制如何能够改善当前的乙肝治疗。
Expert Rev Anti Infect Ther. 2013 Aug;11(8):755-7. doi: 10.1586/14787210.2013.814846.
2
HBV drug resistance: mechanisms, detection and interpretation.乙肝病毒耐药性:机制、检测与解读
J Hepatol. 2006 Mar;44(3):593-606. doi: 10.1016/j.jhep.2006.01.001. Epub 2006 Jan 19.
3
In vitro activity of cepharanthine hydrochloride against clinical wild-type and lamivudine-resistant hepatitis B virus isolates.盐酸金雀花碱对临床野生型和拉米夫定耐药乙型肝炎病毒分离株的体外活性。
Eur J Pharmacol. 2012 May 15;683(1-3):10-5. doi: 10.1016/j.ejphar.2012.02.030. Epub 2012 Feb 24.
4
Tenofovir for patients with lamivudine-resistant hepatitis B virus (HBV) infection and high HBV DNA level during adefovir therapy.替诺福韦用于拉米夫定耐药的乙型肝炎病毒(HBV)感染患者且在阿德福韦治疗期间HBV DNA水平较高者。
Hepatology. 2006 Aug;44(2):318-25. doi: 10.1002/hep.21253.
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In vitro models for studying hepatitis B virus drug resistance.用于研究乙型肝炎病毒耐药性的体外模型。
Semin Liver Dis. 2006 May;26(2):171-80. doi: 10.1055/s-2006-939759.
6
Bortezomib inhibits hepatitis B virus replication in transgenic mice.硼替佐米抑制转基因小鼠乙型肝炎病毒复制。
Antimicrob Agents Chemother. 2010 Feb;54(2):749-56. doi: 10.1128/AAC.01101-09. Epub 2009 Nov 30.
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KNK437 Inhibits Replication and Transcription of the Hepatitis B Virus.KNK437抑制乙型肝炎病毒的复制和转录。
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Betaine Inhibits Hepatitis B Virus with an Advantage of Decreasing Resistance to Lamivudine and Interferon α.甜菜碱抑制乙型肝炎病毒,具有降低对拉米夫定和α干扰素耐药性的优势。
J Agric Food Chem. 2016 May 25;64(20):4068-77. doi: 10.1021/acs.jafc.6b01180. Epub 2016 May 11.
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Viral dynamics in hepatitis B virus infection.乙型肝炎病毒感染中的病毒动力学
Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4398-402. doi: 10.1073/pnas.93.9.4398.

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Efficacy of hepatitis B virus ribonuclease H inhibitors, a new class of replication antagonists, in FRG human liver chimeric mice.FRG 人肝嵌合体小鼠中新型复制拮抗剂乙型肝炎病毒核糖核酸酶 H 抑制剂的疗效。
Antiviral Res. 2018 Jan;149:41-47. doi: 10.1016/j.antiviral.2017.11.008. Epub 2017 Nov 10.
2
In Vitro Enzymatic and Cell Culture-Based Assays for Measuring Activity of HBV RNaseH Inhibitors.用于测量乙肝病毒核糖核酸酶H抑制剂活性的体外酶法和基于细胞培养的分析方法
Methods Mol Biol. 2017;1540:179-192. doi: 10.1007/978-1-4939-6700-1_14.
3
Synergistic Interactions between Hepatitis B Virus RNase H Antagonists and Other Inhibitors.乙型肝炎病毒核糖核酸酶H拮抗剂与其他抑制剂之间的协同相互作用
Antimicrob Agents Chemother. 2017 Feb 23;61(3). doi: 10.1128/AAC.02441-16. Print 2017 Mar.
4
Hepatitis B virus genetic diversity has minimal impact on sensitivity of the viral ribonuclease H to inhibitors.乙肝病毒的基因多样性对病毒核糖核酸酶H对抑制剂的敏感性影响极小。
Antiviral Res. 2016 Nov;135:24-30. doi: 10.1016/j.antiviral.2016.09.009. Epub 2016 Sep 28.
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Purification and enzymatic characterization of the hepatitis B virus ribonuclease H, a new target for antiviral inhibitors.乙型肝炎病毒核糖核酸酶H的纯化及酶学特性研究,抗病毒抑制剂的新靶点
Antiviral Res. 2016 Aug;132:186-95. doi: 10.1016/j.antiviral.2016.06.005. Epub 2016 Jun 17.
6
Functional aspects of intrahepatic hepatitis B virus-specific T cells induced by therapeutic DNA vaccination.治疗性DNA疫苗诱导的肝内乙型肝炎病毒特异性T细胞的功能方面
Mol Ther. 2015 Mar;23(3):578-90. doi: 10.1038/mt.2014.233. Epub 2014 Dec 10.
7
Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity.羟基化托酚酮通过阻断病毒核糖核酸酶H活性来抑制乙型肝炎病毒复制。
Antimicrob Agents Chemother. 2015 Feb;59(2):1070-9. doi: 10.1128/AAC.04617-14. Epub 2014 Dec 1.
8
Hepatitis B virus replication is blocked by a 2-hydroxyisoquinoline-1,3(2H,4H)-dione (HID) inhibitor of the viral ribonuclease H activity.乙型肝炎病毒复制被一种抑制病毒核糖核酸酶H活性的2-羟基异喹啉-1,3(2H,4H)-二酮(HID)所阻断。
Antiviral Res. 2014 Aug;108:48-55. doi: 10.1016/j.antiviral.2014.05.007. Epub 2014 May 20.

本文引用的文献

1
Chronic hepatitis B: what should be the goal for new therapies?慢性乙型肝炎:新疗法的目标应该是什么?
Antiviral Res. 2013 Apr;98(1):27-34. doi: 10.1016/j.antiviral.2013.01.006. Epub 2013 Feb 4.
2
The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes.乙型肝炎病毒核糖核酸酶 H 对人类免疫缺陷病毒核糖核酸酶 H 和整合酶酶的抑制剂敏感。
PLoS Pathog. 2013 Jan;9(1):e1003125. doi: 10.1371/journal.ppat.1003125. Epub 2013 Jan 22.
3
Hepatitis B virus reactivation associated with anti-neoplastic therapy.与抗肿瘤治疗相关的乙型肝炎病毒再激活。
J Gastroenterol Hepatol. 2013 Jan;28(1):31-7. doi: 10.1111/j.1440-1746.2012.07280.x.
4
Restored function of HBV-specific T cells after long-term effective therapy with nucleos(t)ide analogues.核苷(酸)类似物长期有效治疗后乙型肝炎病毒特异性 T 细胞功能的恢复。
Gastroenterology. 2012 Oct;143(4):963-73.e9. doi: 10.1053/j.gastro.2012.07.014. Epub 2012 Jul 14.
5
DNA prime-adenovirus boost immunization induces a vigorous and multifunctional T-cell response against hepadnaviral proteins in the mouse and woodchuck model.DNA 初免-腺病毒加强免疫可诱导小鼠和土拨鼠模型中针对嗜肝病毒蛋白的强烈和多功能 T 细胞应答。
J Virol. 2012 Sep;86(17):9297-310. doi: 10.1128/JVI.00506-12. Epub 2012 Jun 20.
6
Identification of disubstituted sulfonamide compounds as specific inhibitors of hepatitis B virus covalently closed circular DNA formation.鉴定二取代磺胺类化合物作为乙型肝炎病毒共价闭合环状 DNA 形成的特异性抑制剂。
Antimicrob Agents Chemother. 2012 Aug;56(8):4277-88. doi: 10.1128/AAC.00473-12. Epub 2012 May 29.
7
Hepatitis B therapy.乙肝治疗。
Nat Rev Gastroenterol Hepatol. 2011 May;8(5):275-84. doi: 10.1038/nrgastro.2011.33. Epub 2011 Mar 22.
8
Engineering virus-specific T cells that target HBV infected hepatocytes and hepatocellular carcinoma cell lines.工程病毒特异性 T 细胞,以靶向 HBV 感染的肝细胞和肝癌细胞系。
J Hepatol. 2011 Jul;55(1):103-10. doi: 10.1016/j.jhep.2010.10.025. Epub 2010 Nov 23.
9
Kinetics of hepatitis B surface antigen decline during 3 years of telbivudine treatment in hepatitis B e antigen-positive patients.替比夫定治疗乙型肝炎 e 抗原阳性患者 3 年期间乙型肝炎表面抗原下降的动力学。
Hepatology. 2010 Nov;52(5):1611-20. doi: 10.1002/hep.23905.
10
Molecular characterization of intrahepatic and extrahepatic hepatitis B virus (HBV) reservoirs in patients on suppressive antiviral therapy.在接受抑制性抗病毒治疗的患者中,肝内和肝外乙型肝炎病毒(HBV)储库的分子特征。
J Viral Hepat. 2011 Jun;18(6):415-23. doi: 10.1111/j.1365-2893.2010.01321.x.

How further suppression of virus replication could improve current HBV treatment.

作者信息

Tavis John E, Gehring Adam J, Hu Yuan

出版信息

Expert Rev Anti Infect Ther. 2013 Aug;11(8):755-7. doi: 10.1586/14787210.2013.814846.

DOI:10.1586/14787210.2013.814846
PMID:23977931
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4436969/
Abstract
摘要