Departments of Anesthesiology, Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905 USA.
Expert Rev Respir Med. 2013 Dec;7(6):631-46. doi: 10.1586/17476348.2013.834252. Epub 2013 Aug 27.
Mitochondria are autonomous cellular organelles that oversee a variety of functions such as metabolism, energy production, calcium buffering and cell fate determination. Regulation of their morphology and diverse activities beyond energy production are being recognized as playing major roles in cellular health and dysfunction. This review is aimed at summarizing what is known regarding mitochondrial contributions to pathogenesis of lung diseases. Emphasis is given to understanding the importance of structural and functional aspects of mitochondria in both normal cellular function (based on knowledge from other cell types) and in development and modulation of lung diseases such as asthma, chronic obstructive pulmonary disease, cystic fibrosis and cancer. Emerging techniques that allow examination of mitochondria, and potential strategies to target mitochondria in the treatment of lung diseases are also discussed.
线粒体是自主的细胞细胞器，负责监督多种功能，如代谢、能量产生、钙缓冲和细胞命运决定。人们认识到，调节线粒体的形态和除能量产生以外的各种活性，对于细胞健康和功能障碍起着重要作用。本综述旨在总结线粒体对肺部疾病发病机制的贡献。重点是理解线粒体的结构和功能方面在正常细胞功能（基于其他细胞类型的知识）以及在哮喘、慢性阻塞性肺疾病、囊性纤维化和癌症等肺部疾病的发展和调节中的重要性。还讨论了允许检查线粒体的新兴技术，以及在肺部疾病治疗中靶向线粒体的潜在策略。
