Sagar Shakti, Kapoor Himanshi, Chaudhary Nisha, Roy Soumya Sinha
CSIR-Institute of Genomics & Integrative Biology, New Delhi, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad 201002, India.
CSIR-Institute of Genomics & Integrative Biology, New Delhi, India.
Mitochondrion. 2021 May;58:184-199. doi: 10.1016/j.mito.2021.03.005. Epub 2021 Mar 23.
Calcium (Ca) signalling is well known to dictate cellular functioning and fate. In recent years, the accumulation of Ca in the mitochondria has emerged as an important factor in Chronic Respiratory Diseases (CRD) such as Asthma and Chronic Obstructive Pulmonary Disease (COPD). Various reports underline an aberrant increase in the intracellular Ca, leading to mitochondrial ROS generation, and further activation of the apoptotic pathway in these diseases. Mitochondria contribute to Ca buffering which in turn regulates mitochondrial metabolism and ATP production. Disruption of this Ca balance leads to impaired cellular processes like apoptosis or necrosis and thus contributes to the pathophysiology of airway diseases. This review highlights the key role of cytoplasmic and mitochondrial Ca signalling in regulating CRD, such as asthma and COPD. A better understanding of the dysregulation of mitochondrial Ca homeostasis in these diseases could provide cues for the development of advanced therapeutic interventions in these diseases.
钙（Ca）信号传导在决定细胞功能和命运方面广为人知。近年来，线粒体中钙的积累已成为哮喘和慢性阻塞性肺疾病（COPD）等慢性呼吸道疾病（CRD）的一个重要因素。各种报告强调细胞内钙异常增加，导致线粒体活性氧生成，并进一步激活这些疾病中的凋亡途径。线粒体有助于钙缓冲，进而调节线粒体代谢和ATP生成。这种钙平衡的破坏会导致细胞过程受损，如凋亡或坏死，从而导致气道疾病的病理生理学改变。本综述强调了细胞质和线粒体钙信号传导在调节CRD（如哮喘和COPD）中的关键作用。更好地理解这些疾病中线粒体钙稳态的失调可为开发针对这些疾病的先进治疗干预措施提供线索。
