Unidad de Bioquímica y Biología Molecular de Plantas, Centro de Investigacion Científica de Yucatan, Calle 43 No. 130 Chuburna 97205 Mérida Yucatán Mexico.
Curr Top Med Chem. 2013;13(17):2200-7. doi: 10.2174/15680266113139990152.
Argemone mexicana L. (Papaveraceae), accumulates benzylisoquinoline alkaloids, (BIA) derived from tyrosine. Although it was originated in the western region of the USA-Mexico border, it has spread to tropical and subtropical areas around the world. Today, it is used to treat different ailments, given to its antimicrobial, antiparasitic, antimalarial, pesticide, cytotoxic and neurological properties. These effects are related to the presence of different types of BIA's, such as benzophenanthridines (sanguinarine, chelerythrine), protoberberines (berberine) and protopines (protopine, allocryptopine). This review covers the historical medicinal uses of A. mexicana, as well as its current applications. The chemical bases of such effects are discussed in relation to the occurrence of the different types of alkaloids. The biochemical process involved in the synthesis of these types of alkaloids is also described.
墨西哥天芥菜（罂粟科）积累了苯并菲啶类生物碱（BIA），来源于酪氨酸。虽然它原产于美国-墨西哥边境的西部地区，但已传播到世界各地的热带和亚热带地区。如今，它被用于治疗各种疾病，这要归功于它的抗菌、抗寄生虫、抗疟疾、杀虫剂、细胞毒性和神经特性。这些作用与不同类型的 BIA 的存在有关，如苯并菲啶（血根碱、白屈菜红碱）、原小檗碱（小檗碱）和原阿片碱（原阿片碱、阿枯米定）。本综述涵盖了 A. mexicana 的历史药用用途及其当前的应用。还讨论了这些作用的化学基础与不同类型生物碱的发生有关。还描述了合成这些类型生物碱的生化过程。
