Philip Morris International , Rue des Usines 90, 2000 Neuchâtel, Switzerland.
Chem Res Toxicol. 2013 Oct 21;26(10):1430-43. doi: 10.1021/tx400146x. Epub 2013 Sep 17.
Cigarettes with menthol capsules embedded in the filter have been introduced recently in many countries. At the same time, concerns have been expressed that filter performance could be affected by the crushing of the capsule therein, altering mainstream smoke constituent yields, ultimately with the potential to impact the toxicity of these products. The present study investigates the possible mechanisms underlying differences in smoke constituent deliveries following the crushing of a menthol capsule in a cigarette filter. It also includes results from a market survey of a selection of commercial cigarette brands with menthol capsules representing the different designs for this type of product available in different markets worldwide. The yields of 46 Health Canada smoke components were determined according to the International Organization for Standardization (ISO) machine-smoking regime. Data obtained from measurements using cigarettes with the capsule crushed and uncrushed were compared. Except for the intended presence of menthol flavors in smoke, no meaningful differences were identified in the yields of the remaining measured particulate-phase smoke constituents. Regarding the gas-phase smoke constituents, it was found that the delivery of lipophilic volatiles was reduced when the capsule was crushed. Delivery of the other measured gas-phase components remained unaffected. The results from investigations performed in this study did not show any meaningful increase in the yield of smoke constituents listed by Health Canada as a result of crushing the menthol capsule in the cigarette filter.
最近,许多国家都推出了带有薄荷醇胶囊嵌入过滤嘴的香烟。与此同时,人们担心胶囊在过滤嘴中的破碎会影响过滤性能,改变主流烟气成分的产率,最终可能会影响这些产品的毒性。本研究调查了在香烟过滤嘴中压碎薄荷醇胶囊后,烟气成分输送可能存在的差异的潜在机制。它还包括对具有薄荷醇胶囊的商业香烟品牌的市场调查结果,这些品牌代表了在全球不同市场上可用的此类产品的不同设计。根据国际标准化组织(ISO)机器吸烟法规,确定了 46 种加拿大健康成分的产量。比较了使用压碎和未压碎胶囊的香烟进行测量获得的数据。除了在烟气中存在有意添加的薄荷醇味道外,未发现剩余测量的颗粒相烟气成分的产率有任何有意义的差异。关于气相烟气成分,发现当胶囊被压碎时,亲脂性挥发性物质的输送减少。其他测量的气相成分的输送不受影响。本研究进行的调查结果并未表明,由于在香烟过滤嘴中压碎薄荷醇胶囊,加拿大健康署列出的烟气成分的产率有任何有意义的增加。