Jaccard Guy, Belushkin Maxim, Jeannet Cyril, Aldilla Evi Nurlaili, Ongko Wijoyo Andry
PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
Regul Toxicol Pharmacol. 2019 Feb;101:48-52. doi: 10.1016/j.yrtph.2018.11.004. Epub 2018 Nov 14.
Menthol cigarettes account for a significant market share in many countries. However, little recent data exists on menthol levels in cigarettes and in mainstream smoke, limited to some markets or specific cigarette designs, such as cigarettes containing capsules filled with flavoring liquids. Samples of mentholated cigarettes bought worldwide with a variety of cigarette designs were analyzed for menthol content in cigarettes and in cigarette mainstream smoke with two analytical machine smoking regimes. A wide range of menthol content in cigarettes, from 1 to 22 mg/cigarette, was observed. The transfer of menthol to the cigarette mainstream smoke was generally slightly higher than the transfer of nicotine, with a range of 17%-40% using an intense smoking regime and 1%-17% using the ISO smoking regime. For the Tobacco Heating System (THS) 2.2, the menthol content was 12.8 mg/stick, and the transfer of menthol into the aerosol was about 17% with the ISO intense smoking regime, similar to the transfer of nicotine. The menthol content of the novel product THS 2.2 corresponds to the midpoint of the menthol content range of cigarettes, and the transfer of menthol to its aerosol is in the low range of cigarette menthol transfer.
薄荷醇香烟在许多国家占据显著的市场份额。然而，近期关于香烟及主流烟雾中薄荷醇含量的数据很少，仅限于某些市场或特定的香烟设计，如装有调味液胶囊的香烟。使用两种分析机器吸烟模式，对在全球购买的各种设计的薄荷醇香烟样品进行了香烟及香烟主流烟雾中薄荷醇含量的分析。观察到香烟中薄荷醇含量范围很广，为每支香烟1至22毫克。薄荷醇向香烟主流烟雾中的转移通常略高于尼古丁的转移，在高强度吸烟模式下为17% - 40%，在ISO吸烟模式下为1% - 17%。对于烟草加热系统（THS）2.2，薄荷醇含量为每支12.8毫克，在ISO高强度吸烟模式下，薄荷醇向气溶胶中的转移约为17%，与尼古丁的转移情况相似。新型产品THS 2.2的薄荷醇含量处于香烟薄荷醇含量范围的中点，并且薄荷醇向其气溶胶中的转移处于香烟薄荷醇转移的低水平范围。
